Fibroblasts and Osteoblasts in Inflammation and Bone Damage

Advances in Experimental Medicine and Biology
Jason D TurnerPaul-Peter Tak

Abstract

This review discusses the important role fibroblasts play in the process of inflammation and the evidence that these cells may drive the persistence of inflammation. Fibroblasts are key components of the stroma normally involved in maintenance of extracellular matrix and tissue function; however, the term 'fibroblast' is used to describe a heterogeneous population of cells that vary in phenotype both between and within anatomical sites. Fibroblasts possess Toll-like receptors allowing them to respond to pathogen and damage-related signals by producing proinflammatory mediators such as IL-6, PGE2, and GM-CSF and can produce a range of chemokines such as CXCL12, CXCL13, and CXCL8 which attract B and T lymphocytes, monocytes, and neutrophils to sites of inflammation. Interactions between leukocytes and fibroblasts can facilitate increased survival of the leukocytes and modulate phenotypes leading to differential gene expression in the presence of mediators involved in inflammation. Fibroblasts also contribute to collateral tissue damage during inflammation through the production of members of the metalloproteinase family and cathepsins and also through induction of osteoclastogenesis leading to increased bone resorption rates. In ...Continue Reading

Citations

Oct 4, 2019·International Endodontic Journal·A De RossiS Y Fukada
Jan 2, 2020·International Journal of Molecular Sciences·Yiwen ZhangQiong Xu
Oct 23, 2020·Archives of Oral Biology·Marcelo Queiroz D'ÂngeloRodrigo Villamarim Soares

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