PMID: 3762576Oct 1, 1986Paper

Fibroblasts from patients with inherited predisposition to retinoblastoma exhibit normal sensitivity to the mutagenic effects of ionizing radiation

Mutation Research
Y WangJ J McCormick

Abstract

Retinoblastoma (RB) is a cancer of the retina which characteristically occurs in early childhood. Bilateral RB is an inherited form of this disease. Such patients are at greatly increased risk of subsequently developing second tumors in mesenchymal tissue, especially in areas exposed to ionizing radiation therapy. Fibroblasts from bilateral RB patients have been reported to be more sensitive than normal fibroblasts to the cytotoxic effects of ionizing radiation. Because xeroderma pigmentosum patients have a hereditary predisposition to UV-induced cancer and the cells of such patients are abnormally sensitive to the cytotoxic and mutagenic effects of UV radiation, we compared fibroblasts from 6 bilateral RB patients and 3 normal individuals for their sensitivity to the mutagenic effects of cobalt 60, using resistance to 6-thioguanine (TG) as the genetic marker. The results showed no statistically significant difference between the two types of cell lines. The slope of the weighted least squares line representing the frequency of TG-resistant cells induced in the RB populations as a function of dose was 17 +/- 6 (S.E.)/10(6) cells/Gy with an intercept of 0.09 Gy; that for the normal cells was 17 +/- 7/10(6) cells/Gy with an inter...Continue Reading

References

Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R R WeichselbaumJ B Little

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Citations

Nov 1, 1990·Mutation Research
Apr 1, 1993·Cancer Genetics and Cytogenetics·M A HannanD Sigut
Jan 1, 1996·International Journal of Radiation Oncology, Biology, Physics·P J Deschavanne, B Fertil
Nov 1, 1988·Ophthalmology·M C Kincaid
Jan 21, 1991·International Journal of Cancer. Journal International Du Cancer·M A HannanM H Amer
Nov 1, 1990·Mutation Research·V M MaherJ J McCormick

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