Fibrodysplasia ossificans progressiva. An 11-year-old boy treated with a diphosphonate

Acta paediatrica Scandinavica
L BruniC Imperato

Abstract

Fibrodysplasia ossificans progressiva (FOP) is a severe, rare, autosomal dominant, ectopic ossifying condition, with primary involvement of the skeletal muscles associated with skeletal abnormalities. This report concerns an 11-year-old boy suffering from FOP, who presented significant modification of the musculoskeletal structure of the thorax and problems with articular movements. The patient showed progress after treatment with ethane-1-hydroxy-1,1-diphosphonate (EHDP). In fact, using a scintiscanner we were able to observe a significant improvement in symptoms and a recovery of some of the active sites of ossification.

References

Feb 1, 1976·The Journal of Bone and Joint Surgery. British Volume·R SmithC G Woods
Mar 1, 1987·The American Journal of Sports Medicine·J S KirkpatrickG D Rovere
Jan 1, 1986·European Journal of Nuclear Medicine·C J Edeling
Apr 1, 1986·Radiology·J W ReinigM A Zasloff
Oct 18, 1969·Lancet·C A BassettM D Francis
Jan 1, 1982·The Journal of Bone and Joint Surgery. British Volume·J M Connor, D A Evans

❮ Previous
Next ❯

Citations

Mar 21, 2013·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·R K Kriegbaum, S Hillerup
Apr 10, 1999·Postgraduate Medical Journal·S OrmeT J Hendra
Sep 1, 1995·European Journal of Pediatrics·G BuyseP Casaer
Dec 1, 1994·Seminars in Arthritis and Rheumatism·A J BridgesJ Miles
Aug 11, 1998·International Journal of Oral and Maxillofacial Surgery·C Debeney-BruyerreF Guilbert
Jan 1, 1995·Revue de chirurgie orthopédique et réparatrice de l'appareil moteur·E KattiJ C Turpin
Mar 1, 1994·Arquivos de neuro-psiquiatria·E R Tonholo-SilvaL Yoshinaga
Mar 24, 1999·Plastic and Reconstructive Surgery·V ChichareonN Donsakul

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.