PMID: 9422318Jan 9, 1998Paper

Fibroepithelial polyps of the anus: a histologic, immunohistochemical, and ultrastructural study, including comparison with the normal anal subepithelial layer

The American Journal of Surgical Pathology
G M Groisman, S Polak-Charcon

Abstract

Fibroepithelial polyps of the anus (FEPA) are relatively common lesions that have attracted little attention. A series of 40 FEPA, together with sections from normal anal mucosa, were studied histologically, histochemically, immunohistochemically, and ultrastructurally. The polyps consisted of myxoid or collagenous stroma covered by squamous epithelium. Stromal cells with two or more nuclei were found in 30 polyps (80%). In five cases (12%) these cells showed atypical nuclear features. All the polyps harboring atypical cells were of large size. Mast cells were frequently present and sometimes intimately related to the stromal cells. Stromal cells stained positive for vimentin and negative for actin. Desmin was expressed in 30% of the cases. Electron microscopic examination confirmed the fibroblastic and myofibroblastic nature of the stromal cells. Examination of the subepithelial connective tissue from the normal anal mucosa showed bizarre multinucleated cells and mast cell infiltration. It is concluded that FEPA are benign lesions characterized by the presence of mononucleated and multinucleated, sometimes atypical stromal cells showing fibroblastic and myofibroblastic differentiation. The morphologic similarity between FEPA a...Continue Reading

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Citations

Feb 26, 2000·Histopathology·G M GroismanS Polak-Charcon
Jul 11, 2001·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·J S PapiezC A Meynen
Apr 24, 2004·The American Journal of Surgical Pathology·Fatima Eslami-VarzanehDhanpat Jain
Nov 7, 2006·Journal of Cutaneous Pathology·Seng Geok Nicholas GohEduardo Calonje
Mar 31, 2007·Histopathology·M L Wu, X Zhao
Feb 2, 2008·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Briana C Gleason, Sara O Vargas
Jun 20, 2008·Journal of Cutaneous Pathology·Song LuJohn Andrew Carlson
Nov 26, 2009·Virchows Archiv : an International Journal of Pathology·Gaetano MagroMichal Michal
May 30, 2013·International Journal of Surgical Pathology·Bal M Dhungel, Giovanni De Petris
Feb 19, 2016·International Journal of Surgical Pathology·Debra Heller, Theodore Barrett
Apr 13, 1999·The American Journal of Surgical Pathology·T W Beer, N J Carr
Aug 5, 2009·World Journal of Gastroenterology : WJG·Ioannis GalanisKonstantinos Atmatzidis
Nov 10, 2020·Fetal and Pediatric Pathology·Kelley ParkBahig M Shehata
Jun 17, 2008·Annales de pathologie·Denis ChatelainJean-François Fléjou

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