Abstract
Fibrogenesis and inflammation contribute to the progression of cirrhosis. However, it is unknown if these processes also contribute to the development of cirrhotic cardiomyopathy (CCM). Novel magnetic resonance imaging with quantification of the extracellular volume (ECV) provides an estimate of the fibrotic remodelling in the liver and heart. To investigate the relationship between liver and cardiac ECV in cirrhosis and their association with collagen turnover and inflammation. A prospective study of 52 patients with cirrhosis and 14 healthy controls. All patients underwent contrast-enhanced MRI with T1-mapping and quantification of myocardial and liver ECV, biochemical assessments of collagen turnover (PRO-C3, PRO-C5, PRO-C6, collagen type IV degradation fragment, collagen type V degradation fragment, LG1M) and inflammation (TNFα, IL-1β, IL-6, IL-8, IL-18, SDF1α, sCD163, sMR, soluble macrophage mannose receptor). Myocardial and liver ECV were increased in patients compared with healthy controls (myocardial ECV 31.2 ± 5.5% vs 27.4 ± 2.9%, P = 0.037; liver ECV 44.1 ± 9.6% vs 33.7 ± 6.7%, P < 0.001). Myocardial ECV correlated strongly with liver ECV (r = 0.48, P = 0.001) and biomarkers of collagen formation and inflammation (P <...Continue Reading
References
Jun 30, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G La VillaG Laffi
Dec 13, 2002·Scandinavian Journal of Clinical and Laboratory Investigation·H J MøllerS K Moestrup
Apr 16, 2005·Heart·S H PoulsenC E Mogensen
Mar 25, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ali R ManiKevin P Moore
Jul 14, 2010·Journal of Hepatology·Ying-Ying YangSamuel S Lee
Oct 25, 2011·Journal of the American College of Cardiology·Arantxa GonzálezJavier Díez
Sep 12, 2012·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Peter KellmanAndrew E Arai
Aug 2, 2013·Future Microbiology·Sandrine GiraudJean-Philippe Bouchara
Sep 17, 2013·Journal of Hepatology·Rajarshi BanerjeeStefan Neubauer
Oct 12, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Sidsel Rødgaard-HansenHolger Jon Møller
Jul 30, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ekihiro Seki, Robert F Schwabe
Oct 14, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Mette J NielsenKeyur Patel
Apr 10, 2015·Journal of Clinical Gastroenterology·Malte H WehmeyerStefan Lüth
Jun 27, 2015·Digestive Diseases and Sciences·Søren Møller, Flemming Bendtsen
Feb 14, 2016·Heart Failure Reviews·Alexandros BriasoulisDimitris Tousoulis
Jul 9, 2016·Circulation Research·Valentina O PuntmannEike Nagel
Oct 18, 2016·Cardiology Journal·Błażej MichalskiJarosław D Kasprzak
Dec 14, 2016·PloS One·Zhen-Yu ZhangJan A Staessen
Jun 19, 2017·JACC. Cardiovascular Imaging·Shiro NakamoriMasaaki Ito
Oct 11, 2017·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Daniel R MessroghliMatthias G Friedrich
Feb 7, 2018·Hepatology Communications·Michael PraktiknjoJonel Trebicka
Feb 25, 2018·Journal of the American Heart Association·Daniel A DuprezDavid R Jacobs
Apr 13, 2018·Diabetes Care·Daniel G K RasmussenPeter Rossing
May 2, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Signe WieseSøren Møller
Jun 1, 2018·Alimentary Pharmacology & Therapeutics·M J NielsenM Vesterhus
Jun 11, 2018·Journal of Hepatology·Christopher R BradleyIndra Neil Guha
Jun 27, 2018·Radiology·Julian A LuetkensGuido M Kukuk
Aug 31, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Morten A KarsdalDetlef Schuppan
Oct 3, 2018·PloS One·Signe Holm NielsenPaul Cockwell
Nov 12, 2018·Journal of Hepatology·Gideon M HirschfieldUlrich Beuers
Feb 21, 2019·Journal of the American College of Cardiology·Michael R ZileJean Rouleau
May 20, 2019·JACC. Cardiovascular Imaging·Thomas A TreibelErik B Schelbert
Jun 20, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Signe WieseSøren Møller
Jul 26, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Manhal IzzyUNKNOWN Cirrhotic Cardiomyopathy Consortium
Mar 13, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Michael PraktiknjoJonel Trebicka