Fibrogenesis and inflammation contribute to the pathogenesis of cirrhotic cardiomyopathy

Alimentary Pharmacology & Therapeutics
Signe WieseFlemming Bendtsen

Abstract

Fibrogenesis and inflammation contribute to the progression of cirrhosis. However, it is unknown if these processes also contribute to the development of cirrhotic cardiomyopathy (CCM). Novel magnetic resonance imaging with quantification of the extracellular volume (ECV) provides an estimate of the fibrotic remodelling in the liver and heart. To investigate the relationship between liver and cardiac ECV in cirrhosis and their association with collagen turnover and inflammation. A prospective study of 52 patients with cirrhosis and 14 healthy controls. All patients underwent contrast-enhanced MRI with T1-mapping and quantification of myocardial and liver ECV, biochemical assessments of collagen turnover (PRO-C3, PRO-C5, PRO-C6, collagen type IV degradation fragment, collagen type V degradation fragment, LG1M) and inflammation (TNFα, IL-1β, IL-6, IL-8, IL-18, SDF1α, sCD163, sMR, soluble macrophage mannose receptor). Myocardial and liver ECV were increased in patients compared with healthy controls (myocardial ECV 31.2 ± 5.5% vs 27.4 ± 2.9%, P = 0.037; liver ECV 44.1 ± 9.6% vs 33.7 ± 6.7%, P < 0.001). Myocardial ECV correlated strongly with liver ECV (r = 0.48, P = 0.001) and biomarkers of collagen formation and inflammation (P <...Continue Reading

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Citations

Nov 12, 2020·Medicinal Research Reviews·Enrico Maria ZardiDomenico Maria Zardi
Dec 7, 2020·International Journal of Cardiology·Søren Møller

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