Fibroin nanoparticles: a promising drug delivery system.

Drug Delivery
Duy Toan Pham, Waree Tiyaboonchai

Abstract

Fibroin is a dominant silk protein that possesses ideal properties as a biomaterial for drug delivery. Recently, the development of fibroin nanoparticles (FNPs) for various biomedical applications has been extensively studied. Due to their versatility and chemical modifiability, FNPs can encapsulate different types of therapeutic compounds, including small and big molecules, proteins, enzymes, vaccines, and genetic materials. Moreover, FNPs are able to be administered both parenterally and non-parenterally. This review summaries basic information on the silk and fibroin origin and characteristics, followed by the up-to-date data on the FNPs preparation and characterization methods. In addition, their medical applications as a drug delivery system are in-depth explored based on several administrative routes of parenteral, oral, transdermal, ocular, orthopedic, and respiratory. Finally, the challenges and suggested solutions, as well as the future outlooks of these systems are discussed.

References

Mar 17, 1995·Biochemical and Biophysical Research Communications·N MinouraY Imai
Jan 1, 1996·Anti-cancer Drugs·A SparreboomJ H Beijnen
Jan 23, 1999·European Journal of Biochemistry·A KuriokaH Hirano
May 26, 1999·International Journal of Biological Macromolecules·R ValluzziD L Kaplan
Jul 9, 1999·Journal of Biomedical Materials Research·M SantinM Cannas
Feb 13, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·K S SoppimathW E Rudzinski
Apr 20, 2001·Advanced Drug Delivery Reviews·W Mehnert, K Mäder
Aug 29, 2002·Critical Reviews in Therapeutic Drug Carrier Systems·Patrick CouvreurChristine Vauthier
Nov 9, 2002·Biomaterials·Gregory H AltmanDavid L Kaplan
Aug 29, 2003·Nature·Hyoung-Joon Jin, David L Kaplan
Nov 18, 2003·British Journal of Clinical Pharmacology·N R Labiris, M B Dolovich
Feb 24, 2005·International Journal of Pharmaceutics·Derya Gulsen, Anuj Chauhan
Feb 7, 2006·Biomaterials·Chunmei LiDavid L Kaplan
May 9, 2006·International Journal of Biological Macromolecules·Fang XieXuechao Hu
Oct 27, 2006·The Journal of Physical Chemistry. B·Akira MatsumotoDavid L Kaplan
Nov 9, 2006·Advances in Biochemical Engineering/biotechnology·Lakshmi S Nair, Cato T Laurencin
Dec 29, 2007·International Journal of Pharmaceutics·A GiteauJ P Benoit
May 13, 2008·Nature Reviews. Cancer·Klaus Strebhardt, Axel Ullrich
May 27, 2008·Biomaterials·Yongzhong WangDavid L Kaplan
Sep 2, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Esther WenkLorenz Meinel
May 27, 2009·International Journal of Molecular Sciences·Yang Cao, Bochu Wang
Jun 12, 2009·International Journal of Nanomedicine·Vishal GuptaAnshu B Mathur
Dec 1, 2009·Biomaterials·Xiaoqin WangDavid L Kaplan
Jan 2, 2010·Biomaterials·Keiji NumataDavid L Kaplan
Jan 12, 2010·International Journal of Pharmaceutics·Joydip KunduS C Kundu
Mar 12, 2010·Biomaterials·Andreas S LammelThomas R Scheibel
Mar 20, 2010·Advanced Drug Delivery Reviews·Keiji Numata, David L Kaplan
Mar 27, 2010·International Journal of Biological Macromolecules·Paweena WadbuaSineenat Siri
Jul 29, 2010·Nanomedicine·Anshu B Mathur, Vishal Gupta
Nov 10, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Esther WenkLorenz Meinel
Oct 1, 2011·Nature Protocols·Danielle N RockwoodDavid L Kaplan
Jan 1, 2010·Annual Review of Chemical and Biomolecular Engineering·William B LiechtyNicholas A Peppas
Jun 12, 2012·Nanomedicine : Nanotechnology, Biology, and Medicine·Michael L EtheridgeJeffrey McCullough
Jul 28, 2012·Expert Opinion on Drug Delivery·Shirui MaoLuk Chiu Li
Aug 28, 2012·International Journal of Nanomedicine·Andrea TautzenbergerAnita Ignatius
Jan 15, 2013·International Journal of Biological Macromolecules·Sorada KanokpanontPornanong Aramwit
Apr 10, 2013·Biomedical Engineering Online·Pratthana ChomchalaoWaree Tiyaboonchai

❮ Previous
Next ❯

Citations

Jul 3, 2020·Pharmaceutics·Seyoung HongHee Ho Park
Nov 27, 2020·Frontiers in Chemistry·Ya MaBo Xiao
Apr 3, 2021·International Journal of Biological Macromolecules·Ali H KaralyIbrahim M El-Sherbiny
Apr 4, 2021·Pharmaceutics·Mahdi YonesiDaniel González-Nieto
Jul 27, 2021·International Journal of Pharmaceutics·Patricia Diez-EchaveAntonio Abel Lozano-Pérez
Dec 1, 2020·Biomacromolecules·Heike M HeroldThomas Scheibel
Nov 19, 2020·ACS Applied Materials & Interfaces·Sama GhaleiHitesh Handa

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
X-ray
Nuclear
nuclear magnetic resonance
nanoprecipitation
Scanning
Atomic force microscopy
transfection
antisense oligodeoxynucleotides

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Langmuir : the ACS Journal of Surfaces and Colloids
Wei CuiQinghua Lu
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
Lijing JiJingxin Zhu
© 2021 Meta ULC. All rights reserved