Fibrolamellar Hepatocellular Carcinoma: Treatment with Yttrium-90 and Subsequent Surgical Resection

Cardiovascular and Interventional Radiology
Sebastian MafeldPeter Littler

Abstract

We describe a 52-year-old female patient who presented with a 9.5-cm fibrolamellar hepatocellular carcinoma (FL-HCC). The patient was initially unsuitable for surgical resection and therefore underwent transarterial chemoembolization followed by selective internal radiation therapy (SIRT) with Yttrium-90 to downsize the tumour. Following SIRT, the tumour decreased in volume from 350 to 20 cm3 allowing curative (R0) resection with an extended left hepatectomy and reconstruction of IVC. This is the first reported case of FL-HCC treated with SIRT in which, due to the good SIRT response, the patient was downsized to allow curative resection.

References

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Citations

Mar 27, 2019·Journal of Gastrointestinal Cancer·Sebastian MafeldJeremy French
Feb 2, 2019·World Journal of Hepatology·Aakash DesaiDalbir Singh Sandhu
Mar 17, 2021·Journal of Medical Case Reports·Ali Al Zahrani, Ali Alfakeeh
Jul 18, 2021·Current Problems in Cancer·Allison F O'NeillKhashayar Vakili
Nov 19, 2019·ACS Applied Materials & Interfaces·Xiang LiXiaoan Liu

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Methods Mentioned

BETA
surgical resection
biopsy

Software Mentioned

mRECIST

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