Fibromuscular differentiation in deeply infiltrating endometriosis is a reaction of resident fibroblasts to the presence of ectopic endometrium

Human Reproduction
K J A F van KaamP G Groothuis

Abstract

In this study, we characterized the fibromuscular (FM) tissue, typical of deeply infiltrating endometriosis, investigated which cells are responsible for the FM reaction and evaluated whether transforming growth factor-beta (TGF-beta) signaling is involved in this process. FM differentiation and TGF-beta signaling were assessed in deeply infiltrating endometriosis lesions (n = 20) and a nude mouse model of endometriosis 1, 2, 3 and 4 weeks post-transplantation. The FM reaction was evaluated by immunohistochemistry using different markers of FM and smooth muscle cell differentiation (vimentin, desmin, alpha-smooth muscle actin, smooth muscle myosin heavy chain). TGF-beta signaling was assessed by immunostaining for its receptors and phosphorylated Smad. Deeply infiltrating endometriosis lesions contain myofibroblast-like cells that express multiple markers of FM differentiation. Expression of TGF-beta receptors and phospho-Smad was more pronounced in the endometrial component of the lesions than in the FM component. In the nude mouse model, alpha-smooth muscle actin expression was observed in murine fibroblasts surrounding the lesion, but not in human endometrial stroma. FM differentiation in deeply infiltrating endometriosis is...Continue Reading

References

Nov 1, 1992·Fertility and Sterility·M D SpuijbroekJ L Evers
Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T J BroekelmannJ A McDonald
Jun 1, 1990·Fertility and Sterility·F J CornillieP R Koninckx
Mar 1, 1988·Journal of Reproduction and Fertility·G A DunselmanJ L Evers
Nov 10, 1994·The New England Journal of Medicine·W A Border, N A Noble
Oct 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·Y ShiA Zalewski
May 14, 1999·Steroids·R Rupprecht, F Holsboer
Mar 31, 2000·Human Reproduction·V AnafJ Noel
Apr 12, 2000·Histopathology·M Fukunaga
Apr 28, 2000·Fertility and Sterility·P VercelliniP G Crosignani
Aug 1, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T NakamuraH Ueno
Feb 5, 2003·Gynecologic and Obstetric Investigation·Alfonsa PizzoSilvano Marsico
Jun 6, 2003·Pathology International·Tomoko ItogaKatsuyuki Kinoshita
Jul 8, 2003·The Journal of Pathology·G Gabbiani
Jan 1, 1955·Acta Obstetricia Et Gynecologica Scandinavica·G LEVANDER, P NORMANN
Sep 7, 2004·The International Journal of Developmental Biology·Alexis DesmoulièreGiulio Gabbiani
Jan 22, 2005·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Alexis DesmoulièreGiulio Gabbiani
Sep 1, 1996·Human Reproduction Update·E OralA Arici
Oct 1, 1995·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·A B Roberts

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Citations

Jun 15, 2014·Reproductive Biology and Endocrinology : RB&E·Yana B AznaurovaAlex A Zhavoronkov
Mar 19, 2014·Human Reproduction Update·Sang Jun Han, Bert W O'Malley
Mar 5, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Maria-Luisa Barcena de Arellano, Sylvia Mechsner
Mar 13, 2014·Fertility and Sterility·Patrizia CarrarelliFelice Petraglia
Jan 19, 2016·Molecular and Cellular Endocrinology·Yanchun Liang, Shuzhong Yao
May 29, 2012·Journal of Neuroimmunology·Maria Luisa Barcena de ArellanoSylvia Mechsner
Jan 3, 2012·The American Journal of Pathology·M Louise HullWendy V Ingman
Aug 20, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Gülen YerlikayaHeinrich Husslein
Oct 16, 2016·Reproductive Sciences·Maria PerellóFrancisco Carmona
Mar 29, 2018·Reproductive Sciences·Nicola PluchinoHugh S Taylor
Mar 13, 2020·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Julian C Y IpSurya Krishnan
Dec 6, 2017·Human Reproduction·P ViganoE Somigliana
Dec 18, 2012·Oncology Reports·Natsuki KoikeHiroshi Kobayashi
Jun 13, 2018·Human Reproduction Update·Sun-Wei Guo, Patrick G Groothuis
Aug 14, 2018·Molecular and Clinical Oncology·Seza TetikkurtAbdullah Taner Usta
Nov 1, 2018·Reproductive Medicine and Biology·Sun-Wei Guo
May 21, 2020·International Journal of Molecular Sciences·Jieliang ZhouYie Hou Lee
Feb 26, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Zhimin ZhangXiaoguang Yao
Jun 1, 2017·Reproductive Sciences·Maria PerellóFrancisco Carmona
Aug 8, 2014·Journal of Proteome Research·Anni P VehmasGarry L Corthals
Nov 5, 2017·Fertility and Sterility·Stephan GordtsIvo Brosens

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