PMID: 9557783Apr 29, 1998Paper

Fibronectin and the extracellular matrix in the perforating disorders of the skin

The American Journal of Dermatopathology
M B MorganM A Everett

Abstract

Despite detailed microscopic descriptions and clinical observation, little is known regarding the pathogenesis of the perforating disorders of skin, which have traditionally been subdivided into numerous microscopic entities associated with various clinical settings. An increasing body of evidence now suggests that the perforating disorders of skin are akin, and may constitute an expanded single pathologic entity. Each of the classic perforating disorders of skin, including elastosis perforans serpiginosa, perforating folliculitis, reactive perforating collagenosis, Kyrle's disease, and perforating disorder of uremia, have been shown to extrude collagen, elastin, and related extracellular matrix components through the epidermis. Considering a shared pathogenic mechanism among these entities, we explored the possible role of the extracellular matrix, in particular fibronectin, in perforating disorders of skin. Using immunohistochemical and serum determinations of extracellular matrix constituents, including fibronectin, collagen type IV, laminin, and tenascin, we showed consistent serum elevation and/or deposition of fibronectin, in each case, without a commensurate increase in laminin, collagen type IV, and tenascin. We propose...Continue Reading

References

Jan 1, 1992·Cold Spring Harbor Symposia on Quantitative Biology·K M YamadaS E LaFlamme
Mar 1, 1992·International Journal of Dermatology·J W Patterson, P C Brown
Jan 1, 1991·The British Journal of Dermatology·J SchalkwijkE J Mackie
Jun 1, 1985·International Journal of Dermatology·T Y Woo, J E Rasmussen
Jan 1, 1986·Archives of Dermatology·J M SchamrothT P Grieve
Apr 1, 1968·Archives of Dermatology·A H Mehregan, R J Coskey
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Apr 1, 1984·Journal of the American Academy of Dermatology·J W Patterson
Jan 14, 1982·The New England Journal of Medicine·S C PoliakP G Prioleau
Apr 1, 1982·The American Journal of Dermatopathology·R M HurwitzA Handt
Jan 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S Ljunghall, O Ljunggren
Jul 1, 1995·American Journal of Otolaryngology·V SchillingE Kastenbauer
Jun 1, 1995·The Journal of Pathology·E C BergijkJ A Bruijn
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·T YamamotoW A Border
Nov 1, 1993·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S R ShiC R Taylor
Jan 1, 1993·Annual Review of Cell Biology·C Birchmeier, W Birchmeier
Jan 1, 1996·The Journal of Pathology·M A LatijnhouwersJ Schalkwijk

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Citations

Jun 1, 2002·Medicinski pregled·Zoran GolusinNada Vucković
Jan 27, 2010·Indian Journal of Dermatology·Yasmeen J BhatArshad Hussian Bhat
Jan 31, 2012·Actas dermo-sifiliográficas·A I Sánchez-MoyaD García Almagro
Sep 20, 2011·Actas dermo-sifiliográficas·V Fuentelsaz-del BarrioV Parra
Oct 2, 2007·The Journal of Infection·M KhalifaA Omezzine Letaief
Apr 23, 2003·Journal of the European Academy of Dermatology and Venereology : JEADV·B BilezikçiB Demirhan
Aug 31, 2007·The Journal of Dermatology·Hiromi Tsuboi, Kensei Katsuoka
Mar 16, 2006·The British Journal of Dermatology·S R HoqueC A Holden
Jul 21, 2009·Journal of Cutaneous Pathology·Ossama AbbasAbdul-Ghani Kibbi
Mar 27, 2012·Journal of Cutaneous Pathology·Sarah KarramIbrahim Khalifeh
Jul 16, 2010·The Journal of Dermatology·Anthony KarpouzisConstantin Kouskoukis
Jul 22, 2008·Clinics in Dermatology·Mazen S KurbanAbdul-Ghani Kibbi
Sep 7, 2018·The British Journal of Dermatology·F SchauerD Kiritsi
Sep 26, 2003·Journal of Cutaneous Pathology·Maisoun Abdelbaqi-SalhabMichael B Morgan

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