Fibronectin attachment is permissive for IL-1 mediated gene regulation

FEBS Letters
C O OstbergE E Qwarnstrom

Abstract

This study examines the effect of cell-matrix interaction on IL-1 induced gene regulation. In fibroblasts and smooth muscle cells attached to fibronectin, IL-1 caused a pronounced reduction in proteoglycan synthesis, while no reduction occurred in cells plated on bare plastic. Further, fibronectin attachment was permissive for IL-1 mediated suppression of both versican and collagen mRNA levels, initially noted after 4-6 h of IL-1 incubation. Attachment to vitronectin was less potent in influencing regulation, and collagen had no effect, suggesting specificity of the matrix modulation of the IL-1 induced response. Similar fibronectin induced dependence was demonstrated for IL-1 regulation of IL-6 gene expression, supporting the notion of a general effect of fibronectin receptor engagement on IL-1 induced signal transduction.

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Citations

Jan 1, 1995·International Journal of Clinical & Laboratory Research·L A O'Neill
Jun 8, 1999·The Journal of Clinical Investigation·R SinghJ R Sedor
Dec 21, 2005·Archives of Biochemistry and Biophysics·Karim SenniDidier Letourneur
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