PMID: 3764306Jan 1, 1986Paper

Fibronectin in polyethylene glycol precipitates: evidence for a role in immune complexes

Rheumatology International
J S CoppockM W Robinson

Abstract

Fibronectin is involved in the opsonic clearance of particulate material. It is present in plasma and synovial fluid and thus might be expected to have a role in the clearance of immune complexes. We have investigated this in a study of polyethylene glycol (PEG) precipitable material from the serum of patients with rheumatoid arthritis, systemic lupus erythematosus, and other connective tissue disorders. Fibronectin is a significant component of PEG precipitates but the amount present is influenced by the method of preparation: more precipitates at 4 degrees C than at 20 degrees C. Fibronectin precipitation by PEG was considered to be related to immune complexes because: there was no direct relationship between serum fibronectin levels and the amount present in PEG precipitates; radiolabelled purified isolated fibronectin did not precipitate in 4% PEG; there was a direct relationship between the amount of fibronectin in PEG precipitates and the amounts of immunoglobulin G, A, and M. These results indicate that fibronectin is involved in immune complexes in rheumatic diseases, though they do not show it has an important biological role in these circumstances.

References

Jun 20, 1978·Annals of the New York Academy of Sciences·J T Edsall
Feb 28, 1978·Biochemical and Biophysical Research Communications·P J Fraker, J C Speck
Jan 1, 1985·Rheumatology International·D L ScottK W Walton
Jul 1, 1984·Journal of Clinical Pathology·A W Simpson, B J Boughton
Oct 2, 1983·Nature·M J Humphries, S R Ayad
Feb 1, 1984·Seminars in Arthritis and Rheumatism·D L Scott, K W Walton
Jun 1, 1983·The Journal of Experimental Medicine·C G PommierE J Brown
Jan 1, 1981·Collagen and Related Research·E RuoslahtiE G Hayman
Jan 1, 1982·Clinical Science·D L ScottK W Walton
Jan 1, 1981·Journal of Immunological Methods·D L ScottK W Walton
Nov 1, 1981·Collagen and Related Research·E EngvallE Ruoslahti

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Citations

Jan 1, 1987·Rheumatology International·L PuccettiM L Ciompi
Sep 29, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·A M GriffithsD L Scott
Oct 1, 1987·Annals of the Rheumatic Diseases·K E HerbertD L Scott
Jun 1, 1989·Annals of the Rheumatic Diseases·M W RobinsonD L Scott
Jul 3, 2019·Frontiers in Immunology·Stephanie MenikouMichael Levin
Nov 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A RostagnoG Gallo

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