Fibronectin induces the perivascular deposition of cerebrospinal fluid-derived amyloid-β in aging and after stroke

Neurobiology of Aging
Matthew D HoweAkihiko Urayama

Abstract

Cerebral amyloid angiopathy occurs after stroke, but the mechanism underlying the initial amyloid-β deposition is not fully understood. This study investigates whether overexpression of fibronectin and its receptor, integrin-α5, induces the perivascular deposition of cerebrospinal fluid-derived amyloid-β after stroke in young and aged animals. We found that stroke impaired the bulk flow of cerebrospinal fluid into the brain parenchyma and further showed that perivascular amyloid-β deposition was enhanced in aged animals with stroke, which colocalized with integrin-α5 in the basement membrane. Furthermore, we found that stroke dramatically increased the cortical levels of fibronectin and integrin-α5, with further increases in integrin-α5 in aged animals with stroke, fibronectin bound amyloid-β in vitro, and fibronectin administration increased amyloid-β deposition in vivo. Finally, aging and stroke impaired performance on the Barnes maze. These results indicate that fibronectin induces the perivascular deposition of amyloid-β and that increased integrin-α5 further "primes" the aged brain for amyloid-β binding. This provides a novel molecular and physiological mechanism for perivascular amyloid-β deposition after stroke, particul...Continue Reading

Citations

Mar 14, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Anna BersanoUNKNOWN SENECA project
Jun 25, 2020·International Journal of Molecular Sciences·Abby KeableRoxana Octavia Carare
Sep 26, 2020·Frontiers in Aging Neuroscience·Poornima VenkatJieli Chen
Feb 6, 2020·Aging and Disease·Ashok K Shetty, Gabriele Zanirati
Nov 27, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Monica Gireud-GossAkihiko Urayama
Dec 18, 2020·Frontiers in Physiology·Matthew D HoweAkihiko Urayama
Mar 30, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sonia Sanchez-BezanillaLin Kooi Ong
Sep 29, 2021·The Journal of Clinical Investigation·Louise D McCulloughVenugopal Reddy Venna

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

Related Papers

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics
M Tomonaga
Nō to shinkei = Brain and nerve
M Yamada
BMJ Case Reports
Navneet Sharma, Sameer Vyas
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
Anagha P ParkarCornelia Fischer-Bredenbeck
© 2022 Meta ULC. All rights reserved