Fibronectin stimulates human lung carcinoma cell growth by inducing cyclooxygenase-2 (COX-2) expression

International Journal of Cancer. Journal International Du Cancer
ShouWei HanJesse Roman

Abstract

Tobacco use is the most important risk factor for the development of lung carcinoma. One characteristic shared by tobacco-related lung diseases is altered lung connective tissue content and composition. In particular, tobacco results in increased expression of fibronectin (FN), a matrix glycoprotein implicated in lung development, injury and repair and in tumor cell invasion. We hypothesized that excessive deposition of FN in lung might promote lung carcinoma cell proliferation. Consistent with this hypothesis, we found that FN stimulated human lung carcinoma cell proliferation and diminished apoptosis in vitro, and that this effect was mediated through the integrin alpha5beta1 and associated with upregulation of cyclooxygenase-2 (COX-2) mRNA and protein expression, and increased prostaglandin E2 (PGE2) biosynthesis. The stimulatory effect of FN on COX-2 was blocked by the specific COX-2 inhibitor NS-398 and by inhibitors of protein kinase C (PKC), Calphostin C, and extracellular signal-regulated kinases (Erks), PD98095. Electrophoretic mobility shift assays revealed that FN increased the nuclear binding activity of cyclic AMP response element binding protein (CREB) and CCAAT/enhancer-binding protein (C/EBP), 2 proteins known t...Continue Reading

References

Feb 1, 1986·The American Journal of the Medical Sciences·W C Vial
Nov 5, 1997·Experimental Cell Research·J ParkerG Krishnaswamy
Nov 2, 1999·Biochemical and Biophysical Research Communications·D J Wadleigh, H R Herschman
Apr 6, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·B K BolesJ Roman
Aug 10, 2000·The Journal of Biological Chemistry·J ShaoR N DuBois
Oct 12, 2000·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M Katori, M Majima
Nov 15, 2000·Critical Reviews in Clinical Laboratory Sciences·E Fosslien
Jan 3, 2001·American Journal of Physiology. Renal Physiology·Z AbassiJ Winaver
Apr 26, 2001·The Journal of Biological Chemistry·M DohadwalaS M Dubinett
Jun 9, 2001·Endocrine-related Cancer·L R HoweA J Dannenberg
Jul 27, 2001·Journal of Cancer Research and Clinical Oncology·W DempkeH J Schmoll
Sep 27, 2001·Journal of Cellular Physiology·E H Danen, K M Yamada
Jan 12, 2002·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·N NankiT Ishida
Jan 17, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jeffrey E MichaelsonJesse Roman
Mar 7, 2002·American Journal of Physiology. Cell Physiology·Randy C MifflinDon W Powell
Jun 27, 2002·Seminars in Cancer Biology·J Labat-Robert
Sep 18, 2002·The EMBO Journal·Aristides G EliopoulosPhilip N Tsichlis
Jan 10, 2003·The Journal of Clinical Endocrinology and Metabolism·Maddalena IllarioMario Vitale
Feb 8, 2003·The Journal of Clinical Endocrinology and Metabolism·Shouwei Han, Neil Sidell
Feb 18, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Markus J LeskinenPetri T Kovanen
Mar 8, 2003·International Journal of Gastrointestinal Cancer·Young-Eun JooSei-Jong Kim

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Citations

Apr 17, 2012·International Journal of Cell Biology·David G Menter, Raymond N Dubois
Jan 29, 2005·American Journal of Respiratory Cell and Molecular Biology·ShouWei HanJesse Roman
Jun 30, 2007·American Journal of Respiratory Cell and Molecular Biology·Ying ZhengShouWei Han
Jan 19, 2010·American Journal of Respiratory Cell and Molecular Biology·Jesse RomanShouWei Han
Sep 13, 2005·Respiratory Research·Tom Hsun-Wei HuangBasil D Roufogalis
Apr 4, 2007·Annals of the New York Academy of Sciences·Eu-Soo LimSung-Hoon Kim
May 7, 2008·Journal of Cellular Biochemistry·R I VijiP R Sudhakaran
Oct 1, 2008·Experimental Cell Research·Pertteli SalmenperäAntti Vaheri
Sep 15, 2006·Journal of Cellular Physiology·Oliver Jay BroomAnita Sjölander
Apr 13, 2005·International Journal of Cancer. Journal International Du Cancer·ShouWei Han, Jesse Roman
Jul 24, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Allan RamirezJesse Roman
Apr 9, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·ShouWei HanJesse Roman
May 24, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Shouwei HanJesse Roman
Mar 10, 2016·Oncotarget·Xinjian LiuChuan-Yuan Li
Oct 23, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hye Gwang JeongKeon Wook Kang
Oct 27, 2012·Breast Cancer Research : BCR·Brigitte BisaroPaola Defilippi
Jul 30, 2017·International Journal of Molecular Sciences·Dimakatso Alice SenthebaneKevin Dzobo
Apr 28, 2009·Molecular BioSystems·Jeffrey D RitzenthalerJesse Roman
Mar 19, 2021·Journal of Experimental & Clinical Cancer Research : CR·Sheila SpadaPaola Nisticò

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