Fibronectin type III domain containing 5 attenuates NLRP3 inflammasome activation and phenotypic transformation of adventitial fibroblasts in spontaneously hypertensive rats

Journal of Hypertension
Li LingGuo-Qing Zhu

Abstract

Phenotypic transformation of adventitial fibroblasts is important in the pathogenesis of hypertension. This study was designed to determine whether fibronectin type III domain containing 5 (FNDC5) alleviates the phenotypic transformation of adventitial fibroblasts in hypertension and the underlying mechanisms. Experiments were carried out in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) and primary aortic adventitial fibroblasts. FNDC5 was downregulated and NLRP3 inflammasome was activated in aortic adventitia of SHR. FNDC5 overexpression attenuated adventitial fibroblasts phenotypic transformation, excessive synthesis and secretion of matrix components, NLRP3 inflammasome activation and inflammation in adventitial fibroblasts from SHR. Moreover, FNDC5 overexpression reduced NADPH oxidase 2 (NOX2) expression and reactive oxygen species (ROS) production in adventitial fibroblasts from SHR. Similarly, exogenous FNDC5 inhibited adventitial fibroblasts phenotypic transformation, expression of matrix components, NLRP3 inflammasome activation and NOX2 expression in adventitial fibroblasts from SHR. FNDC5 overexpression in rats attenuated phenotypic transformation, inflammation and reactive oxygen species (ROS) pro...Continue Reading

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Citations

Dec 29, 2019·Physiological Reports·Tao WangFrans H H Leenen
Feb 26, 2019·Oxidative Medicine and Cellular Longevity·Dan ChenGuo-Qing Zhu
Apr 18, 2019·Nature Reviews. Immunology·Grant R DrummondChristopher G Sobey
Jan 19, 2021·Medicinal Research Reviews·Carolina PellegriniVincenzo Calderone
Dec 24, 2019·The American Journal of Pathology·Maria G Tinajero, Avrum I Gotlieb
Jul 1, 2020·Molecular and Cellular Endocrinology·Miriane de OliveiraCélia Regina Nogueira

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