Fibrosarcomatous changes and expression of CD34+ and apolipoprotein-D in dermatofibrosarcoma protuberans.

Clinical Sarcoma Research
Emanuela PalmeriniStefano Ferrari

Abstract

Dermatofibrosarcoma protuberans (DFSP) is a relatively common soft-tissue tumor. A more aggressive appearing fibrosarcoma may arise in DFSP, changing its biological behavior. CD34 and apolipoprotein-D are highly expressed in DFSP, but their prognostic significance is uncertain. DFSP and fibrosarcomatous-DFSP (FS-DFSP) patients referred to our institute between 1982 and 2009 were identified. Fibrosarcomatous changes, expression of CD34 and apolipoprotein-D were evaluated. 40 patients, (median age 43 years, 55% males) were identified. Tumor was located in the limbs in 60%, in the trunk in 40%. Thirty-seven patients had localized and 3 had metastatic disease. Thirteen (32%) patients were FS-DFSP. All but one underwent surgery with adequate surgical margins in 72%. 7 FS-DFSP received also radiotherapy (RT). Chemotherapy was administered to 3 patients with FS-DFSP. With a median follow-up of 49 months, the 5-OS was 90%. Local recurrence rate was 23%: 42% FS-DFSP, 15% DFSP. Metastases developed in three FS-DFSP patients. The 5-year EFS was 70% in localized patients. Histology (DFSP 75% vs. FS-DFSP 52%, p = 0.002), surgical margins (adequate 74% vs. inadequate 55%, p = 0.02), site (limb 47% vs. trunk 100%), CD34 expression (CD34 posit...Continue Reading

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Citations

Apr 24, 2014·Journal of the American Academy of Dermatology·Christine A LiangChrysalyne D Schmults
Jun 2, 2015·Expert Review of Anticancer Therapy·Piotr Rutkowski, Maria Debiec-Rychter
Jan 15, 2015·Journal of the American Academy of Dermatology·Paul M HoeslyJulia S Lehman
Aug 21, 2016·The Surgical Clinics of North America·Jeffrey Reha, Steven C Katz
Aug 31, 2019·Dermatologic Clinics·Aubrey AllenOmar P Sangüeza
May 11, 2021·World Journal of Clinical Cases·Li DingZhao-Gen Cai
Oct 26, 2021·Frontiers in Physiology·Diego Sanchez, Maria D Ganfornina

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