Fibrosis: a distinguishing feature in the pathology of neural leprosy

Memórias do Instituto Oswaldo Cruz
Sérgio Luiz Gomes AntunesEuzenir Nunes Sarno

Abstract

Fibrosis in the peripheral nerve is the end stage of leprous neuropathy and the cause of the resulting permanent neural function impairments. Preventive measures to avoid this irreversible pathological state are a relief strategy for leprosy sufferers. The present study describes the frequency of fibrosis along with its characterisation and pathogenic development. Six-hundred-and-thirteen nerve samples were sorted from 278 neural leprosy (NL) and 335 non-leprosy neuropathy patients (ON). The total number of samples was histologically examined by routine staining methods (haematoxylin-eosin, Wade staining and Gomori's trichrome) and fibrosis was evaluated via semi-quantitative estimation. Fibrosis was most frequent in the NL group (33% against 0.4% in ON) while fibrosis in association with endoneurial microfasciculation was found in 38 (41.3%) of the NL samples in the examination of semithin sections. Pericytic activation in the perivascular environment was confirmed to be the source of the fibroblasts and perineurial cells delimiting microfascicles. End-stage fibrosis in leprosy displays an arrangement of microfascicles devoid of neural components (i.e., Schwann cells and axons) lined by an intermediate phenotype of fibroblasti...Continue Reading

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Citations

Jul 28, 2020·Transactions of the Royal Society of Tropical Medicine and Hygiene·Diogo Fernandes Dos SantosIsabela Maria Bernardes Goulart
Dec 22, 2020·Muscle & Nerve·Sérgio Luiz Gomes AntunesAmilton Antunes Barreira
Mar 13, 2021·Immunological Reviews·Anouk van Hooij, Annemieke Geluk

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Methods Mentioned

BETA
biopsy
biopsies
irradiate

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