Fibrosis and loss of smooth muscle in the corpora cavernosa precede corporal veno-occlusive dysfunction (CVOD) induced by experimental cavernosal nerve damage in the rat.

The Journal of Sexual Medicine
Monica G FerriniNestor F Gonzalez-Cadavid

Abstract

Corporal veno-occlusive dysfunction (CVOD), which usually is associated with a loss of smooth muscle cells (SMC) and an increase in fibrosis within the corpora cavernosa, can be induced by an injury to the cavernosal nerves. The corporal tissue expresses inducible nitric oxide synthase (iNOS), presumably as an antifibrotic and SMC-protective response. We studied the temporal relationship in the corpora between the expression of iNOS, other histological and biochemical changes, and the development of CVOD, after bilateral cavernosal nerve resection (BCNR) in the rat. Rats underwent either BCNR or sham operation. Cavernosometry was performed 1, 3, 7, 15, 30, and 45 days (N = 8/groups) after surgery. Penile tissue sections were subjected to Masson trichrome staining for SMC and collagen, and immunodetection for alpha smooth muscle actin, iNOS, neuronal NOS (nNOS), endothelial NOS (eNOS), proliferating cell nuclear antigen (PCNA), and terminal transferase dUTP nick end labeling (TUNEL). Quantitative western blot analysis was done in homogenates. Time course on the development of fibrosis and CVOD. Following BCNR, CVOD was detectable 30 days later, and it became more pronounced by 45 days. In contrast, the SMC/collagen ratio in the ...Continue Reading

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Citations

Mar 20, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jorge E ToblliNestor F Gonzalez-Cadavid
Jun 11, 2014·Cell and Tissue Research·Bodong LvZhaodian Chen
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Dec 3, 2014·The Journal of Sexual Medicine·Tao LiuXiang Fang
Aug 9, 2011·The Journal of Sexual Medicine·Ruibao ChenZhangqun Ye
Jan 14, 2012·The Journal of Sexual Medicine·João P M de CarvalhoLuciano Alves Favorito
Jun 18, 2011·The Journal of Sexual Medicine·Masaki KimuraBridget F Koontz
Jun 28, 2011·The Journal of Sexual Medicine·Zili ZuoYong Cheng
Apr 15, 2010·The Journal of Sexual Medicine·John P MulhallGerald Brock
Nov 6, 2010·The Journal of Sexual Medicine·Eric Chung, Gerald B Brock
Dec 20, 2011·The Journal of Urology·Sena F SezenArthur L Burnett
May 31, 2011·The Urologic Clinics of North America·Clarisse Mazzola, John P Mulhall
Jan 15, 2013·International Journal of Urology : Official Journal of the Japanese Urological Association·Yasuhiro KaihoYoichi Arai
Apr 6, 2016·The Journal of Sexual Medicine·Nelson BennettMichael Krychman
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Oct 28, 2018·Nature Reviews. Urology·Uros MilenkovicFabio Castiglione
Mar 10, 2010·Nature Reviews. Urology·Nestor F Gonzalez-Cadavid, Jacob Rajfer

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