PMID: 9420636Oct 1, 1994Paper

Fibrosis and myocardial ACE: possible substrate and independence from circulating angiotensin II

Journal of Cardiac Failure
Y Sun, K T Weber

Abstract

In order to determine the relation between myocardial fibrosis and (1) angiotensin converting enzyme (ACE) binding density, (2) receptor binding of ACE-related peptides, angiotensin II (AngII) and bradykinin (BK), and (3) the regulation of myocardial ACE by circulating Ang II, we used in vitro quantitative autoradiography to localize and assess ACE ([125I]351A), AngII receptor (125I[Sar1, IIe8]AngII), and BK receptor ([125I]Tyr8) binding densities in the rat myocardium. The experimental groups were (1) AngII (9 micrograms/h subcutaneously) or aldosterone (0.75 microgram/h subcutaneously in uninephrectomized rats on a high-sodium diet) administered by implanted minipump to chronically increase or decrease circulating AngII, respectively, (2) unoperated, untreated age- and sex-matched control rats, and (3) age- and sex-matched uninephrectomized control rats on a high-sodium diet. In the same heart studied at 2, 4, and 6 weeks of hormone treatment, serial sections were assessed for myocardial (hematoxylin and eosin) and fibrillar collagen (picrosirius red) morphology. The authors found that (1) marked ACE binding was coincident with sites of fibrous tissue that appeared in both ventricles as either a perivascular fibrosis of intra...Continue Reading

References

Jan 1, 1992·Clinical and Experimental Pharmacology & Physiology. Supplement·C I JohnstonB Jackson
Nov 1, 1991·Circulation Research·L B TanK T Weber
Jan 1, 1991·Circulation Research·H YamadaA O Mendelsohn
Feb 1, 1991·Clinical and Experimental Pharmacology & Physiology·C I JohnstonB Fabris
Apr 1, 1990·Clinical and Experimental Pharmacology & Physiology·B FabrisC I Johnston
Jul 1, 1990·International Journal of Cardiology·A M AllenF A Mendelsohn
Jun 27, 1989·Biochemistry·M R Ehlers, J F Riordan
Dec 1, 1989·Journal of Molecular and Cellular Cardiology·K T WeberE P Carroll
Aug 1, 1988·Circulation·G P HodsmanC I Johnston
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R A Skidgel, E G Erdös
May 1, 1985·Hypertension·J NussbergerH R Brunner

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