Fibrosis in the peritoneum induced by scirrhous gastric cancer cells may act as "soil" for peritoneal dissemination

Cancer
M YashiroM Sowa

Abstract

Peritoneal metastases are one reason for the poor prognosis of scirrhous gastric cancer. However, the mechanism of peritoneal metastasis remains unclear. We therefore investigated the interaction between gastric cancer cells and peritoneal fibroblasts, in vivo and in vitro. A human scirrhous gastric cancer cell line, OCUM-2MD3, and a human peritoneal fibroblast cell line, NF-2P, were established in our laboratory. We then investigated the effect of OCUM-2MD3 cells on the peritoneum of nude mice and on the proliferation of NF-2P cells, the effect of NF-2P cells on the migratory capability of OCUM-2MD3 cells, and the peritoneal fibrosis on the development of peritoneal metastasis. The proliferation of peritoneal fibroblasts was recognized in areas with and without cancer cell infiltration. Serum-free conditioned medium from the OCUM-2MD3 cells had induced peritoneal fibrosis in vivo and significantly stimulated the proliferation of NF-2P cells in vitro. The molecular weight (molecular weight ratio 25,000-43,000) of the growth factors produced by the OCUM-2MD3 cells was estimated by gel filtration high performance liquid chromatography. The migratory capability of the OCUM-2MD3 cells was significantly increased by the presence of ...Continue Reading

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Citations

Dec 31, 2004·BMC Gastroenterology·Marc JansenVolker Schumpelick
Feb 6, 2009·World Journal of Gastroenterology : WJG·Di NaHui-Mian Xu
Feb 28, 2013·International Journal of Oncology·Tomoya TsukadaTetsuo Ohta
Oct 2, 2003·International Journal of Cancer. Journal International Du Cancer·Shigenari HashimotoShun'ichiro Taniguchi
Aug 17, 2004·International Journal of Colorectal Disease·Marc JansenVolker Schumpelick
Jun 28, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Susann FörsterWolfgang Kemmner
Aug 12, 2020·Cancer Metastasis Reviews·Leela Rani AvulaChristine Alewine
Apr 24, 2014·International Journal of Oncology·Shin AkagawaMasao Tanaka
Mar 21, 2020·Frontiers in Cell and Developmental Biology·Pablo Astudillo
Jul 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hiroaki TanakaKosei Hirakawa

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