Fibrosis-related biomarkers and large and small vessel disease: the Cardiovascular Health Study

Atherosclerosis
Isha AgarwalKenneth J Mukamal

Abstract

Fibrosis has been implicated in a number of pathological, organ-based conditions of the liver, kidney, heart, and lungs. The objective of this study was to determine whether biomarkers of fibrosis are associated with vascular disease in the large and/or small vessels. We evaluated the associations of two circulating biomarkers of fibrosis, transforming growth factor-β (TGF-β) and procollagen type III N-terminal propeptide (PIIINP), with incident peripheral artery disease (PAD) and subclinical macrovascular (carotid intima-media thickness, flow-mediated vasodilation, ankle-brachial index, retinal vein diameter), and microvascular (retinal artery diameter and retinopathy) disease among older adults in the Cardiovascular Health Study. We measured TGF-β and PIIINP from samples collected in 1996 and ascertained clinical PAD through 2011. Measurements of large and small vessels were collected between 1996 and 1998. After adjustment for sociodemographic, clinical, and biochemical risk factors, TGF-β was associated with incident PAD (hazard ratio [HR] = 1.36 per doubling of TGF-β, 95% confidence interval [CI] = 1.04, 1.78) and retinal venular diameter (1.63 μm per doubling of TGF-β, CI = 0.23, 3.02). PIIINP was not associated with inci...Continue Reading

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Citations

Jun 14, 2016·Canadian Journal of Physiology and Pharmacology·Ying-Hua HeJun Li
Jan 14, 2017·Stroke; a Journal of Cerebral Circulation·Kristin MüllerMarkus Schwaninger
Dec 28, 2019·Journal of the American Heart Association·Robert S RosensonLisandro D Colantonio
May 22, 2018·BioMed Research International·Klaudia MazurekJarosław Markowski

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