Fibrous testing papers for fluorescence trace sensing and photodynamic destruction of antibiotic-resistant bacteria.

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Long ZhaoXiaohong Li

Abstract

The increasing prevalence of antibiotic-resistant bacteria needs rapid identification and efficient destruction routes. This study proposes testing paper derived from electrospun fibrous mats and aggregation-induced emission (AIE) probes for trace sensing and simultaneous destruction of antibiotic-resistant E. coli. Aptamers are conjugated on fibers for selective capture of E. coli, and the capture capability can be regenerated via rinsing with salt solution. Hydroxyl tetraphenylethene (TPE) is linked with two cephalosporin molecules to construct TPE-Cep probes, and the fluorescence emission is turned on specifically in the presence of β-lactamase, which is a critical marker for screening resistant bacteria. Fibrous mats are lit up only in the presence of antibiotic-resistant bacteria, and the fluorescence intensity changes could be statistically fitted into an equation for quantitative analysis. Fibrous strips display apparent color changes from blue to green for a visual readout of bacterial levels, and the limit of detection (LOD) is much lower than those of previous paper substrates. In addition, the TPE-Cep probes could produce reactive oxygen species (ROS) under room light illumination to kill the captured bacteria. Thus,...Continue Reading

References

Nov 1, 1978·Antimicrobial Agents and Chemotherapy·H C Neu, K P Fu
Mar 2, 2010·Biochemical and Biophysical Research Communications·Tomohisa KatoKenichi Hatanaka
Nov 22, 2011·Biosensors & Bioelectronics·Longhua Guo, Dong-Hwan Kim
Jul 11, 2012·Biosensors & Bioelectronics·Su Jin LeeMan Bock Gu
Dec 2, 2014·Nature Reviews. Microbiology·Jessica M A BlairLaura J V Piddock
Mar 20, 2015·ACS Applied Materials & Interfaces·Engui ZhaoBen Zhong Tang
Jul 7, 2015·Future Medicinal Chemistry·Adelaide AlmeidaJoão P C Tomé
Dec 26, 2015·Environmental Monitoring and Assessment·Ryan A BlausteinYakov A Pachepsky
Feb 8, 2016·Biosensors & Bioelectronics·Tianxun HuangXiaomei Yan
Jan 10, 2017·ACS Applied Materials & Interfaces·Long ZhaoXiaohong Li
Jun 24, 2017·Chemical Society Reviews·Linda VáradiPaul W Groundwater

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Citations

Jul 28, 2020·International Journal of Molecular Sciences·Nevina E Trunzo, Ka Lok Hong
Aug 4, 2021·Advanced Healthcare Materials·Qinggele BorjihanYing-Wei Yang
Aug 31, 2021·Frontiers in Chemistry·Shin A YoonMin Hee Lee

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Methods Mentioned

BETA
imaging techniques
Fluorescence
PCA
amidation
Scanning electron microscopy
X-ray
biosensor

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