PMID: 15348694Sep 7, 2004Paper

Fibrous wound repair associated with biodegradable poly-L/D-lactide copolymer implants: study of the expression of tenascin and cellular fibronectin

Journal of Materials Science. Materials in Medicine
R KontioI Virtanen

Abstract

Extracellular matrix (ECM) proteins are known to play a role in inflammatory and hyperplastic processes. Our aim in the present study was to study the distribution of tenascin (Tn), cellular fibronectins (cFn) and myofibroblasts around biodegradable poly-L/D-lactide (PLA) implants with monoclonal antibodies (MAb). Ethylene-oxide and gamma-irradiation sterilized PLA plate-type implants were inserted into the dorsal subcutaneous tissue of ten adult rabbits. Follow-up times were 4, 12, 16, 36 and 48 wk. Only some inflammatory cells were observed. In electron microscopy, a close coherence between the implant and the stromal tissue was seen. Immunoreactivity for Tn, cFn and alpha-actin was detected as a distinct layer bordering the implant, regardless of the sterilization method for the first 36 wk. From week 36 onwards, Tn immunoreactivity was downregulated while cFn immunoreactivity still persisted. A moderate upregulation for myofibroblasts was seen on the week 48 specimens, when hydrolysation of PLA implant had started. The persistent content of myofibroblasts, Tn and cFn suggests a prolonged wound healing produced by PLA implants. The absence of Tn at the week 48 specimens suggests that cFn, rather than Tn may be needed for alp...Continue Reading

Citations

May 18, 2004·International Journal of Oral and Maxillofacial Surgery·R KontioP Laine
Jun 26, 2004·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Risto Kontio
Mar 17, 2006·International Journal of Oral and Maxillofacial Surgery·M EkholmR Suuronen

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