Fibrovascular ingrowth into hydroxyapatite and porous polyethylene orbital implants wrapped with acellular dermis

Ophthalmic Plastic and Reconstructive Surgery
Manoj M ThakkerP A Rubin

Abstract

Acellular dermis is a frequently used wrapping material for hydroxyapatite (HA) and porous polyethylene (PP) orbital implants. In an animal model, we determined by histology the extent of fibrovascular ingrowth within orbital implants wrapped in acellular dermis at 6 and 12 weeks after surgery. Four Yucatan minipigs were used for the study. Two minipigs had HA implants and two had PP implants. Implants were harvested at 6 or 12 weeks after surgery and were examined histologically for fibrovascular ingrowth. There was complete fibrovascularization of HA implants harvested at both 6 and 12 weeks after surgery. The PP implant harvested at 6 weeks had incomplete fibrovascularization, whereas the PP implant harvested at 12 weeks had complete fibrovascular ingrowth. There was no histologic evidence of inflammation seen in any of the orbital implants. On gross and histologic examination, the wraps were found to persist on the surface of all orbital implants, with little histologic evidence of inflammation localized to the acellular dermis. Acellular dermis wraps support fibrovascularization of both HA and PP orbital implants. Additionally, acellular dermis does not incite significant inflammation in association with HA and PP orbital ...Continue Reading

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Citations

Dec 18, 2013·Acta Biomaterialia·Francesco BainoMonica Ferraris
May 3, 2007·Survey of Ophthalmology·David SamiRobert Petersen
Mar 22, 2006·Ophthalmic Plastic and Reconstructive Surgery·Arianne P OriáAna Letícia G de Souza
Jun 12, 2020·Tissue Engineering. Part B, Reviews·Thomas SpäterMatthias W Laschke
Feb 21, 2009·Orbit·Katya TambeSoupramanien Sandramouli

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