[Fibrovascular transformation of CNV in nAMD after long-term anti-VEGF therapy : Methodological evaluation of quantifying morphological changes].

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Marius BookDaniel Pauleikhoff

Abstract

Under long-term anti-VEGF therapy neovascular age-related macular degeneration (nAMD) may result in fibrovascular transformation of choroidal neovascularization (CNV). So far there is a lack of definitions on how a differentiated quantification of the associated morphological changes can best be carried out. This pilot study aimed to define the most appropriate imaging modalities. In 56 eyes with fibrotic CNV after at least 2 years of anti-VEGF therapy and at least 12 intravitreal anti-VEGF injections, the following imaging modalities were investigated with respect to the delimitation of vascular and fibrous portions of CNV as well as associated atrophy of retinal pigment epithelium (RPE) and disruption of the ellipsoid zone (EZ): multicolor imaging (MC), fundus autofluorescence (FAF), fluorescein angiography (FA) and indocyanine green angiography (ICGA), spectral domain optical coherence tomography (SD-OCT) and OCT angiography (OCTA). The vascular portion of fibrotic CNV was best visualized by OCTA, the fibrous portion by SD-OCT. The RPE atrophy was best delimitated by FAF, but differentiation was also possible by MC and ICGA. Disruption of the EZ could be delineated by SD-OCT b‑scan. The use of MC is suitable for visualizatio...Continue Reading

References

Apr 13, 2012·Journal of Ophthalmology·Young Gun ParkYoung Jung Roh
Dec 10, 2013·Ophthalmology·Ebenezer DanielUNKNOWN Comparison of Age-related Macular Degeneration Treatments Trials Research Group
Aug 20, 2014·The British Journal of Ophthalmology·Ursula Schmidt-ErfurthUNKNOWN European Society of Retina Specialists
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Nov 17, 2016·International Journal of Retina and Vitreous·Madeline YungDavid Sarraf
Feb 25, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Marie-Louise FareckiDaniel Pauleikhoff
Dec 13, 2017·Progress in Retinal and Eye Research·Richard F SpaideGiovanni Staurenghi
May 17, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Daniel PauleikhoffKai Rothaus
May 18, 2020·Ophthalmology Retina·Sean D AdreanFerhina S Ali

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