PMID: 25743806Mar 7, 2015Paper

Fibulin-3 as a diagnostic biomarker in patients with malignant mesothelioma

Asian Pacific Journal of Cancer Prevention : APJCP
Halide KayaAbdurrahman Senyigit

Abstract

New tumour biomarkers are being intensely investigated for malignant mesothelioma (MM). Fibulin-3 is produced in MM but its role remains uncertain. The aim of this study was to evaluate the validity of measuring serum fibulin-3 in the diagnosis and prognosis of MM. This prospective study was performed on 43 patients and 40 healthy controls who were admitted to our hospital between January 2012 and January 2014. Data from MM patients, including demographic and clinical features, routine laboratory data, levels of serum fibulin-3, and treatment outcomes were defined as potential prognostic factors. The receiver operating characteristic (ROC) curve for fibulin-3 was used to detect the cut-off value with highest sensitivity and specificity. Univariate survival analysis was performed using the Kaplan-Meier method in patients with MM. Afterwards, the possible factors identified with univariate analyses were entered into the cox regression analysis. Our results revealed that patients with MM had significantly higher serum levels of fibulin-3 than controls. The results showed that the best cut-off point was 36.6 ng/ml with an AUC (area under the curve)=0.976, sensitivity=93.0% and specificity=90.0. In our study, the initial significant...Continue Reading

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Citations

Feb 3, 2016·Osong Public Health and Research Perspectives·Jae-Eun LeeSo-Youn Shin
Jul 28, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Michele CarboneShakun Malik
Apr 11, 2017·Environmental Research·Venerando RapisardaCarla Loreto
Jan 19, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hedy L KindlerRaffit Hassan
Feb 9, 2017·British Journal of Cancer·David T ArnoldNick A Maskell
Jun 27, 2019·Biomarkers in Medicine·Caterina LeddaVenerando Rapisarda
Jan 7, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andrea NapolitanoHaining Yang
Jul 24, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Harvey I PassChandra M Goparaju
Jun 12, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Selina TsimKevin G Blyth
Oct 6, 2020·Thoracic Surgery Clinics·Harvey I PassChandra M Goparaju

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