Fibulin-3 promotes muscle-invasive bladder cancer

Oncogene
A L HanE T Keller

Abstract

Urothelial carcinoma is the most common type of bladder cancer and can be categorized as either non-muscle-invasive (Ta-T1) or muscle-invasive (⩾T2). The majority of bladder cancers are non-muscle-invasive at presentation; however, the recurrence rate for these tumors is high and a subset can progress to T2. In this study, we aimed to identify genes differentially expressed between T1 vs T2 bladder cancer to identify key regulators of bladder cancer progression and/or invasion. We performed RNA-Seq on T1 and T2 bladder cancer tissues and used publicly available bladder cancer profiling studies to prioritize differentially expressed genes for validation and functional assessment. This integrative approach nominated an extracellular matrix glycoprotein, fibulin-3 (FBLN3, also known as EFEMP1), as being highly expressed in T2 vs T1 bladder cancer and aggressive vs indolent disease. We confirmed the overexpression of fibulin-3 in ⩾T2 vs non-muscle-invasive bladder cancer (NMIBC) by quantitative reverse transcriptase-PCR. Consistent with these findings, fibulin-3 expression level correlated with the invasive ability of several bladder cancer cell lines and modulation of fibulin-3 expression directly affected invasion. Fibulin-3 knoc...Continue Reading

References

Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·V G TusherG Chu
Jan 31, 2004·PharmacoEconomics·Marc F BottemanRobert Hauser
Aug 20, 2005·Nature Reviews. Cancer·Xue-Ru Wu
Mar 11, 2006·The Biochemical Journal·James BeattieDavid J Flint
Mar 16, 2007·Neoplasia : an International Journal for Oncology Research·Daniel R RhodesArul M Chinnaiyan
Feb 12, 2009·Molecular Cancer Research : MCR·Hendrik SeeligerChristiane J Bruns
Mar 12, 2009·Matrix Biology : Journal of the International Society for Matrix Biology·S SercuJ Merregaert
Oct 6, 2009·Experimental Eye Research·Youwen Zhang, Lihua Y Marmorstein
Oct 7, 2009·Biological Chemistry·Peter CamajChristiane J Bruns
Nov 6, 2009·Molecular Cancer Research : MCR·Bin HuMariano S Viapiano
Apr 10, 2010·Gynecologic Oncology·Song En-linWang Hua-qiao
Jul 29, 2011·Pathology Oncology Research : POR·Zhu WangJiandong Tong
May 4, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gottfrid SjödahlMattias Höglund
Jun 23, 2012·Nature·Catherine S GrassoScott A Tomlins
Apr 4, 2013·Science Signaling·Jianjiong GaoNikolaus Schultz
Oct 22, 2013·Oncology Reports·Shun XuXin Zhang
Jan 31, 2014·Nature·UNKNOWN Cancer Genome Atlas Research Network
Feb 1, 2014·Carcinogenesis·Xiaojun ChenLin Zhang
Feb 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey S DamrauerWilliam Y Kim
Sep 12, 2014·Journal of Cellular and Molecular Medicine·Mafalda AlmeidaCarmen Jerónimo
Dec 31, 2014·The Journal of Biological Chemistry·María ArechederraAlmudena Porras
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jun 19, 2016·The Journal of Urology·Sam S ChangJames M McKiernan

❮ Previous
Next ❯

Citations

Feb 23, 2019·Prevention Science : the Official Journal of the Society for Prevention Research·Colleen E JanczewskiMichael J Brondino
Jun 13, 2018·The FEBS Journal·Pierre-Benoit AnceyEtienne Meylan
May 28, 2019·International Journal of Molecular Sciences·Shinsuke KikuchiTakahiro Ochiya
Apr 14, 2020·BioMed Research International·Zhuo WangZhongwei Lin
Jan 27, 2019·Nature Protocols·Guadalupe Lorenzatti HilesMark L Day
Jan 19, 2021·Cancer Nanotechnology·Md Nazir HossenPriyabrata Mukherjee
Feb 21, 2021·Antioxidants & Redox Signaling·Carola Muñoz-MontesinoCoralia I Rivas
Apr 27, 2021·Bioactive Materials·Komal AbhangeYuan Wan
Dec 23, 2021·Clinical and Translational Medicine·Xiaoling YingWeidong Ji

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.