Fibulins and their role in cardiovascular biology and disease.

Advances in Clinical Chemistry
Claudia CangemiLars M Rasmussen

Abstract

Fibulins are a group of extracellular matrix proteins of which many are present in high amounts in the cardiovascular system. They share common biochemical properties and are often found in relation to basement membranes or elastic fibers. Observations in humans with specific mutations in fibulin genes, together with results from genetically engineered mice and data from human cardiovascular tissue suggest that the fibulin family of proteins play important functional roles in the cardiovascular system. Moreover, fibulin-1 circulates in high concentrations in plasma and may function as a cardiovascular disease marker.

Citations

Dec 4, 2015·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Gontse G MokwatsiRuan Kruger
Jul 19, 2017·Antioxidants & Redox Signaling·David Labrousse-AriasMaría J Calzada
Jun 6, 2018·Scientific Reports· YasminKevin M O'Shaughnessy
Mar 7, 2019·BMC Systems Biology·Lyudmila H PastushkovaIrina M Larina
Aug 18, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chao-Zhi TangWen-Sheng Wang

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