Ficolin-1 is a promising therapeutic target for autoimmune diseases

International Immunology
Michihito KatayamaToru Hirano

Abstract

Previously, we reported that mRNA expression of ficolin-1 (FCN1), a component of the complement lectin pathway, is elevated in peripheral blood mononuclear cells of patients with vasculitis syndrome, and that FCN1-positive cells infiltrate into inflamed regions in patient specimens. In addition, we reported that the serum FCN1 concentration is elevated in patients with Kawasaki disease (KD), a pediatric vasculitis, but dramatically decreases after intravenous immunoglobulin (IVIG) treatment. Furthermore, we showed that FCN1 binds to IgG1 in a pull-down assay. These results suggested that removal of FCN1 may be a therapeutic mechanism of IVIG. In this study, we prepared anti-FCN1 monoclonal antibody (mAb) and examined its therapeutic potential in mice treated with Candida albicans water-soluble fraction (CAWS), which induces KD-like vasculitis in the coronary artery. Indeed, treatment with anti-FCN1 mAb decreased the histological score of vasculitis (P = 0.03). To investigate the role of FCN1, we assessed blood samples of patients with various autoimmune diseases and demonstrated that serum levels of FCN1 were elevated not only in patients with vasculitis, but also in those with rheumatoid arthritis. Additionally, FCN1-targeted ...Continue Reading

References

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Citations

May 29, 2019·Current Opinion in Rheumatology·Honorio Torres-AguilarSergio R Aguilar-Ruiz
Mar 13, 2020·Biological & Pharmaceutical Bulletin·Chiho YanaiYoshiyuki Adachi
Aug 22, 2020·Autoimmunity·Cristhine PieczarkaIara Jose de Messias-Reason
Jul 19, 2019·Frontiers in Pediatrics·Akihiro NakamuraKenji Hamaoka
Jan 9, 2019·Frontiers in Immunology·Sandra Jeremias CatarinoIara Jose Messias-Reason
Dec 15, 2019·Journal of Molecular and Cellular Cardiology·Fumiya AnzaiMasafumi Takahashi
Apr 25, 2021·Mathematical Biosciences and Engineering : MBE·Xiaodong XiaLijun Wang
Aug 5, 2021·Signal Transduction and Targeted Therapy·Danyang Li, Minghua Wu

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Software Mentioned

ProteinSimple
Compass
JMP
BLAST

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