Ficolin-3-mediated lectin complement pathway activation in patients with subarachnoid hemorrhage

Neurology
Elisa R ZanierMaria-Grazia De Simoni

Abstract

To assess the involvement of ficolin-3, the main initiator of the lectin complement pathway (LCP), in subarachnoid hemorrhage (SAH) pathology and outcome. In this preliminary exploratory study, plasma concentration of ficolin-3 and of ficolin-3-mediated functional LCP activity was measured, along with that of other LCP initiators (mannose-binding lectin, ficolin-2, and ficolin-1), C3 activation products, and soluble C5b-9 terminal complex, in a prospective cohort of 39 patients with SAH and 20 healthy controls. The following parameters were recorded: SAH severity, assessed using the World Federation of Neurosurgical Societies grading scale; vasospasm, defined as neuro-worsening with angiographic confirmation of vessel narrowing; cerebral ischemia, defined as hypodense lesion on CT scan performed before discharge; and 6-month outcome, assessed using the Glasgow Outcome Scale. In patients, no changes were detected for ficolin-3 compared with controls. Notably, however, ficolin-3-mediated functional LCP activity was reduced. Low levels of plasma ficolin-3 and ficolin-3-mediated functional LCP activity were related to SAH severity, vasospasm, and cerebral ischemia. Moreover, ficolin-3 functional LCP activity was decreased in patien...Continue Reading

Citations

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Nov 27, 2014·Frontiers in Cellular Neuroscience·Franca OrsiniMaria-Grazia De Simoni
Mar 13, 2016·Journal of Biomolecular Screening·Matteo StravalaciMarco Gobbi
Nov 5, 2016·Stroke; a Journal of Cerebral Circulation·Stefano Fumagalli, Maria-Grazia De Simoni
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Apr 1, 2017·Frontiers in Immunology·Stefano FumagalliMaria-Grazia De Simoni
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Nov 14, 2020·Journal of Neuroinflammation·Jeppe Sillesen MatzenSøren Bache

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