Fidelity of muscle fibre reinnervation modulates ageing muscle impact in elderly women

The Journal of Physiology
Vita SonjakRussell T Hepple

Abstract

Susceptibility to age-related muscle atrophy relates to the degree of muscle denervation and the capacity of successful reinnervation. However, the specific role of denervation as a determinant of the severity of muscle aging between populations with low versus high physical function has not been addressed. We show that prefrail/frail elderly women exhibited marked features of muscle denervation, whereas world class octogenarian female master athletes showed attenuated indices of denervation and greater reinnervation capacity. These findings suggest that the difference in age-related muscle impact between low- and high-functioning elderly women is the robustness of the response to denervation of myofibers. Ageing muscle degeneration is a key contributor to physical frailty; however, the factors responsible for exacerbated vs. muted ageing muscle impact are largely unknown. Based upon evidence that susceptibility to neurogenic impact is an important determinant of the severity of ageing muscle degeneration, we aimed to determine the presence and extent of denervation in pre-frail/frail elderly (FE, 77.9 ± 6.2 years) women compared to young physically inactive (YI, 24.0 ± 3.5 years) females, and contrast these findings to high-fu...Continue Reading

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Citations

Sep 5, 2019·The Journal of Physiology·W David Arnold, Brian C Clark
Apr 30, 2020·American Journal of Physiology. Cell Physiology·Laura E TeigenRobert H Fitts
Jan 17, 2020·Cells·Maria-Eleni Anagnostou, Russell T Hepple
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Mar 7, 2021·Aging Cell·Marita A WallaceKeith Baar
Feb 22, 2021·Ageing Research Reviews·Osvaldo DelbonoMaria Laura Messi
Jun 22, 2021·Geriatrics & Gerontology International·Ahmed H AbdelhafizAlan J Sinclair
Jun 24, 2021·American Journal of Physiology. Cell Physiology·Casper SoendenbroeAbigail L Mackey
Aug 19, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Giorgio VarescoVianney Rozand

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