Field-amplified sample stacking capillary electrophoresis with electrochemiluminescence applied to the determination of illicit drugs on banknotes

Journal of Chromatography. a
Yuanhong XuErkang Wang

Abstract

Capillary electrophoresis (CE) with Ru(bpy)3(2+) electrochemiluminescence (ECL) detection system was established to the determination of contamination of banknotes with controlled drugs and a high efficiency on-column field-amplified sample stacking (FASS) technique was also optimized to increase the ECL intensity. The method was illustrated using heroin and cocaine, which are two typical and popular illicit drugs. Highest sample stacking was obtained when 0.01 mM acetic acid was chosen for sample dissolution with electrokinetical injection for 6 s at 17 kV. Under the optimized conditions: ECL detection at 1.2 V, separation voltage 10.0 kV, 20 mM phosphate-acetate (pH 7.2) as running buffer, 5 mM Ru(bpy)3(2+) with 50 mM phosphate-acetate (pH 7.2) in the detection cell, the standard curves were linear in the range of 7.50x10(-8) to 1.00x10(-5) M for heroin and 2.50x10(-7) to 1.00x10(-4) M for cocaine and detection limits of 50 nM for heroin and 60 nM for cocaine were achieved (S/N = 3), respectively. Relative standard derivations of the ECL intensity and the migration time were 3.50 and 0.51% for heroin and 4.44 and 0.12% for cocaine, respectively. The developed method was successfully applied to the determination of heroin and ...Continue Reading

References

Aug 13, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·F TagliaroM Marigo
Feb 25, 2000·Therapeutic Drug Monitoring·G ManettoF Tagliaro
Apr 25, 2003·Forensic Science International : Synergy·James F CarterJoanna Parry
Jul 1, 2005·Rapid Communications in Mass Spectrometry : RCM·Karl A EbejerRichard Sleeman
Oct 31, 2008·Talanta·Nicole AnastosSimon W Lewis

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Citations

Dec 25, 2010·Analytical and Bioanalytical Chemistry·Longhua GuoGuonan Chen
Feb 18, 2011·Analytical and Bioanalytical Chemistry·Qihong CaiGuonan Chen
Aug 15, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shuyu ZhangHui Wei
Oct 12, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Biyang DengQiumei Xu
Nov 24, 2007·Journal of Chromatography. a·Steven L SimpsonShigeru Terabe
Aug 19, 2008·Journal of Pharmaceutical and Biomedical Analysis·Paul S FrancisNeil W Barnett
Dec 16, 2011·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Jing Li, Erkang Wang
Mar 17, 2007·Electrophoresis·Feliciano Priego Capote, María Dolores Luque de Castro
May 17, 2007·Chemistry : a European Journal·Tao LiShaojun Dong
Dec 7, 2007·Electrophoresis·Franco Tagliaro, Federica Bortolotti
Jul 23, 2008·Journal of Separation Science·Yuegang ZuoJohn Fritz
Jul 2, 2010·Chemical Society Reviews·Lianzhe Hu, Guobao Xu
Jun 22, 2010·Electrophoresis·Francisco J LaraAurelia Ibáñez Velasco
Dec 8, 2011·Electrophoresis·Heide R RabanesJoselito P Quirino
Dec 15, 2010·Drug Testing and Analysis·Jacqui L AdcockPaul S Francis

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