Field avian metapneumovirus evolution avoiding vaccine induced immunity

Vaccine
Elena CatelliClive J Naylor

Abstract

Live avian metapneumovirus (AMPV) vaccines have largely brought turkey rhinotracheitis (TRT) under control in Europe but unexplained outbreaks still occur. Italian AMPV longitudinal farm studies showed that subtype B AMPVs were frequently detected in turkeys some considerable period after subtype B vaccination. Sequencing showed these to be unrelated to the previously applied vaccine. Sequencing of the entire genome of a typical later isolate showed numerous SH and G protein gene differences when compared to both a 1987 Italian field isolate and the vaccine in common use. Experimental challenge of vaccinated birds with recent virus showed that protection was inferior to that seen after challenge with the earlier 1987 isolate. Field virus had changed in key antigenic regions allowing replication and leading to disease in well vaccinated birds.

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Citations

Apr 20, 2011·Avian Diseases·Jorge Luis ChacónAntonio J Piantino Ferreira
Jul 23, 2011·Avian Pathology : Journal of the W.V.P.A·Paulo Anselmo FelippeClarice Weis Arns
Aug 23, 2011·Avian Pathology : Journal of the W.V.P.A·Caterina LupiniElena Catelli
Sep 15, 2015·Avian Pathology : Journal of the W.V.P.A·Sandra HartmannSilke Rautenschlein
Feb 20, 2018·Transboundary and Emerging Diseases·C M JardineD Ojkic
Jul 10, 2020·Veterinary Research·Giovanni FranzoMattia Cecchinato

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