PMID: 9421889Jan 1, 1997Paper

Field-effect transistor array for monitoring electrical activity from mammalian neurons in culture

Biosensors & Bioelectronics
Andreas OffenhäusserWolfgang Knoll

Abstract

A field-effect transistor (FET) array has been fabricated and used for recording of electrical signals from neural cells. The array consists of p-channel FETs with non-metalized gates. The size of the gates of the 16 FETs are from 28 x 12 microns2 down to 10 x 4 microns2 and are arranged in a 4 x 4 matrix on 200 microns centers. For the device fabrication process we have especially focused on high sensitivity, good long-term stability in physiological conditions, and sufficient reduced signal-to-noise ratio. Special care was taken on the encapsulation technique of the device to allow surface modification based on the self-assembly technique. It can be shown that the microelectronic device surface can be modified with a synthetic peptide linked to the surface. Tailoring of the surface composition using this method allows hippocampal neurons to adhere and grow for days. More importantly, these cells develop typical electrical characteristics when cultured on this artificial surface. Using this approach neuron-FET couplings were recorded.

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Citations

Oct 2, 2004·European Biophysics Journal : EBJ·Sven IngebrandtAndreas Offenhäusser
Mar 17, 2004·Journal of Neuroscience Methods·Shalini PrasadMihrimah Ozkan
Feb 13, 2001·Journal of Neuroscience Methods·M SchollA Offenhäusser
Feb 13, 2001·Trends in Biotechnology·A Offenhäusser, W Knoll
Sep 7, 2001·Biosensors & Bioelectronics·S IngebrandtA Offenhäusser
Feb 27, 2003·Biosensors & Bioelectronics·S IngebrandtA Offenhäusser
Jan 5, 2002·Journal of Pharmacological and Toxicological Methods·C K YeungW Knoll
Nov 14, 2012·Nano Letters·Jens WallysMartin Eickhoff
Jul 5, 2007·Journal of the Royal Society, Interface·Günter WrobelAndreas Offenhäusser
Nov 10, 2001·Annual Review of Biomedical Engineering·A Folch, M Toner
Sep 16, 1999·Journal of Biomaterials Science. Polymer Edition·J RüheA Offenhäusser
May 14, 2004·Critical Reviews in Biomedical Engineering·Nianzhen LiAlbert Folch
Feb 4, 2014·Nanoscale Research Letters·Ki-Young LeeHeon-Jin Choi
Feb 20, 2013·Current Opinion in Biotechnology·Moria KwiatFernando Patolsky
Aug 16, 2005·Biophysical Journal·Günter WrobelAndreas Offenhäusser
Jul 9, 2003·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·U B SleytrD Pum
Oct 4, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A NatarajanJ J Hickman
Jul 21, 2005·Biosensors & Bioelectronics·Sven MeyburgAndreas Offenhäusser
Jul 17, 2012·Biosensors & Bioelectronics·D KoppenhöferS Ingebrandt
Jan 23, 2015·Frontiers in Neuroscience·Marie Engelene J ObienUrs Frey
Apr 26, 2016·Biosensors·Ciril Reiner-RozmanWolfgang Knoll
Apr 12, 2011·Medical Engineering & Physics·Anthony H D GrahamJohn Taylor
Jun 21, 2017·Science Advances·Jonathan RivnayGeorge G Malliaras
Jan 1, 2009·Sensors·Kazuo Nakazato
Apr 24, 2002·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·C SprösslerA Offenhäusser
Jul 2, 2016·Essays in Biochemistry·Vivek Pachauri, Sven Ingebrandt
Oct 12, 2002·The Analyst·Michael J Schöning, Arshak Poghossian
Mar 12, 2021·Nanoscale Research Letters·Anh Thi NguyenYi-Chia Chou
Jun 7, 2014·Chemical Reviews·Qingjun LiuPing Wang
Feb 5, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Nam Seob BaekSang-Don Jung

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