Field evaluation of the 22 rapid diagnostic tests for community management of malaria with artemisinin combination therapy in Cameroon

Malaria Journal
Innocent M AliRose G F Leke

Abstract

All suspected cases of malaria should receive a diagnostic test prior to treatment with artemisinin-based combinations based on the new WHO malaria treatment guidelines. This study compared the accuracy and some operational characteristics of 22 different immunochromatographic antigen capture point-of- malaria tests (RDTs) in Cameroon to inform test procurement prior to deployment of artemisinin-based combinations for malaria treatment. One hundred human blood samples (50 positive and 50 negative) collected from consenting febrile patients in two health centres at Yaoundé were used for evaluation of the 22 RDTs categorized as "Pf Only" (9) or "Pf + PAN" (13) based on parasite antigen captured [histidine rich protein II (HRP2) or lactate dehydrogenase (pLDH) or aldolase]. RDTs were coded to blind technicians performing the tests. The sensitivity, specificity, and predictive values of the positive and negative tests (PPV and NPV) as well as the likelihood ratios were assessed. The reliability and some operational characteristics were determined as the mean values from two assessors, and the Cohen's kappa statistic was then used to compare agreement. Light microscopy was the referent. Of all RDTs tested, 94.2 % (21/22) had sensiti...Continue Reading

References

Mar 1, 1991·Transactions of the Royal Society of Tropical Medicine and Hygiene·B M Greenwood, J R Armstrong
Sep 1, 1996·Social Science & Medicine·S C McCombie
Jul 4, 1998·Lancet·P E KofoedL Rombo
Nov 16, 2004·BMJ : British Medical Journal·Hugh ReyburnChristopher J M Whitty
Aug 17, 2006·Nature Reviews. Microbiology·David BellJohn W Barnwell
Jan 18, 2008·BMJ : British Medical Journal·Yoel LubellAnne Mills
Feb 5, 2008·The Journal of Infectious Diseases·Heidi HopkinsGrant Dorsey
Jul 21, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anders Björkman, Andreas Mårtensson
Feb 12, 2011·PLoS Medicine·UNKNOWN malERA Consultative Group on Diagnoses and Diagnostics
Dec 22, 2011·Malaria Journal·Peter W GethingSimon I Hay

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Citations

Oct 18, 2016·Journal of Parasitology Research·James Osei-YeboahEmmanuel Alote Allotey
Aug 6, 2020·International Journal of Environmental Research and Public Health·Adela Gómez-LuqueLuis Carlos Gómez-Nieto
Mar 7, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Loick P Kojom FokoVineeta Singh

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Methods Mentioned

BETA
light microscopy

Software Mentioned

Clearview
ParaHIT

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