Field induced cell proliferation and death in a thick epithelium

BioRxiv : the Preprint Server for Biology
Niladri SarkarFrank Julicher

Abstract

We study the dynamics of a thick polar epithelium subjected to the action of both an electric and a flow field in a planar geometry. We develop a generalized continuum hydrodynamic description and describe the tissue as a two component fluid system. The cells and the interstitial fluid are the two components and we keep all terms allowed by symmetry. In particular we keep track of the cell pumping activity for both solvent flow and electric current and discuss the corresponding orders of magnitude. We study the growth dynamics of tissue slabs, their steady states and obtain the dependence of the cell velocity, net cell division rate, and cell stress on the flow strength and the applied electric field. We find that finite thickness tissue slabs exist only in a restricted region of phase space and that relatively modest electric fields or imposed external flows can induce either proliferation or death.

Related Concepts

Cell Division
Cessation of Life
Epithelium
Interstitial Fluid
Anatomical Space Structure
Cell Proliferation
Description
Active Transmembrane Transporter Activity
Cell Stress Process
Specimen Component

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