Field-induced wooden-tip electrospray ionization mass spectrometry for high-throughput analysis of herbal medicines

Analytica Chimica Acta
Yunyun YangZhong-Ping Yao

Abstract

This study demonstrates the first application of field-induced wooden-tip electrospray ionization (ESI) mass spectrometry (MS) for high-throughput analysis of herbal medicines. By application of an opposite and sample-contactless high voltage on the MS inlet rather than wooden tips, a high-throughput analysis device is easily set up, and a relatively fast analysis speed of 6 s per sample was successfully achieved. In addition, fast polarity switching between positive and negative ion detection mode is readily accomplished, which provides more complete chemical information for quality assessment and control of herbal medicines. By using the proposed method, various active ingredients present in different herbal medicines were rapidly detected, and the obtained mass spectra were served as the samples' fingerprints for tracing the origins, establishing the authenticity, and assessing the quality consistency and stability of herbal medicines. Our experimental results demonstrated that field-induced wooden-tip ESI-MS is a desirable method for high-throughput analysis of herbal medicines, with promising prospects for rapidly differentiating the origin, determining the authenticity, and assessing the overall quality of pharmaceuticals.

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Citations

Nov 14, 2015·Analytical Chemistry·Julia Laskin, Ingela Lanekoff
Feb 27, 2016·Bioanalysis·Nicholas E ManickeChengsen Zhang
Dec 15, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Melody Yee-Man WongZhong-Ping Yao
May 28, 2016·BMC Complementary and Alternative Medicine·Lydia Aziato, Hannah Ohemeng Antwi
Sep 14, 2016·Analytica Chimica Acta·Ho-Yi WongZhong-Ping Yao
Apr 17, 2019·Journal of Food and Drug Analysis·Tsz-Tsun NgZhong-Ping Yao
Oct 17, 2017·Analytical and Bioanalytical Chemistry·Xianjiang LiHuwei Liu
Jun 1, 2018·Journal of Analytical Methods in Chemistry·Federica BianchiMaria Careri
Sep 25, 2021·Journal of Separation Science·Jaime Millán-SantiagoSoledad Cárdenas

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