Field isolates of Mycoplasma ovipneumoniae exhibit distinct cytopathic effects in ovine tracheal organ cultures

Zentralblatt für Veterinärmedizin. Reihe A
M NiangM L Kaeberle

Abstract

Ovine tracheal ring explants were infected with four different Mycoplasma ovipneumoniae and one M. arginini field isolate and their ability to induce cytopathic effects was tested by measuring ciliary activity and intracellular calmodulin release. Infected tracheal rings showed significantly decreased ciliary activity as compared to the non-infected control rings. There were, however, marked differences between isolates in the onset and severity of the effects which correlated with their ability to produce hydrogen peroxide. Infected tracheal rings released more calmodulin than the non-infected controls. The amount of calmodulin released also varied between isolates, and somewhat reflected the degree of loss of ciliary activity in the corresponding rings induced by the different isolates. Light and electron microscopic examinations of infected tracheal rings revealed disorganisation and sloughing of the epithelium, and association of mycoplasmas only with the cilia. Following repeated in vitro passages, the organisms had reduced ability to inhibit ciliary activity which correlated with decreased hydrogen peroxide production. Addition of catalase to the organ cultures delayed loss of ciliary activity. These results suggest that ...Continue Reading

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Citations

Jul 12, 2011·Journal of Bacteriology·Falong YangHua Yue
Dec 21, 2012·Preventive Veterinary Medicine·Thomas E BesserWilliam Foreyt
Mar 2, 2010·Veterinary Immunology and Immunopathology·W ShahzadRicardo Francisco Rosenbusch
May 5, 2004·Fish & Shellfish Immunology·Andrew C Barnes, Anthony E Ellis
Nov 30, 2018·Journal of Applied Physiology·James L NuzzoSimon C Gandevia
Apr 6, 2018·The Journal of Sports Medicine and Physical Fitness·Ahmad H AlghadirEinas S Al-Eisa
Sep 19, 2018·Acta Veterinaria Scandinavica·Lisa LindströmKarin Vargmar
Aug 26, 2019·Journal of Microbiological Methods·Melissa G AckermanThomas E Besser
Jul 13, 2021·Journal of Veterinary Research·Jin-Yu ZhaoJun-Yuan Wu

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