PMID: 6972796Jan 5, 1981Paper

Field potential induced by injection of potassium ion into the frog retina: a test of current interpretations of the electroretinographic (ERG) b-wave

Brain Research
M Fujimoto, T Tomita

Abstract

Using excised frog retinas, the field potential induced by mechanical intraretinal injection of K+ Reinger's was mapped by a penetrating electrode. The high K+ Ringer's contained 75 mM K+ and the amount per injection was of a sphere about 40-50 micron in diameter. The K+ injection pipette was so made that it also served for recording potentials at the site of K+ injection. The study revealed that: (1) a maximum negativity is produced at the depth of K+ injection; and that (2) the negativity subsides in both directions, proximally and distally; but that (3) when recording from the retinal surfaces, the vitreal side becomes positive relative to the receptor side, irrespective of the retinal depth of K+ injection, excepting for the innermost layer of some 20 micron in thickness where some uncertainty remains. The results indicated that the "neutral zone", as defined as a zone where a high K+ produces no potential differences between the opposite retinal surfaces, is localized very close to the inner limiting membrane. Recent interpretations of the b-wave on the Müller cell hypothesis are discussed on the basis of our results.

References

Nov 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R P KlineJ E Dowling
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Citations

Oct 30, 1985·Documenta Ophthalmologica. Advances in Ophthalmology·I GottlobR Pflug
Jul 15, 1981·Documenta Ophthalmologica. Advances in Ophthalmology·R Hanitzsch
Jan 1, 1986·Documenta Ophthalmologica. Advances in Ophthalmology·W M KozakK K Elmer
Jan 1, 1981·Vision Research·T Tomita, T Yanagida
Jan 1, 1988·Vision Research·I GottlobF K Tuppy
Mar 1, 1994·Neuroscience Research·M Fujimoto, H Yanase
Jan 1, 1985·Neuroscience·R P KlineJ E Dowling
Jan 1, 1989·The Journal of General Physiology·R A Stockton, M M Slaughter
Jan 1, 1986·Neuroscience Research. Supplement : the Official Journal of the Japan Neuroscience Society·M Fujimoto, T Tomita
Apr 1, 1986·Experimental Eye Research·M L MolnàrG K Molnàr
May 10, 1984·Nature·A R Gardner-Medwin
Jan 1, 1981·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·U FuchsP Winiecki

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