Field stimulation responses of rat urinary bladder detrusor smooth-muscle. Dependence upon slow calcium channel activity determined by K+ depolarization and calcium antagonists

General Pharmacology
H Huddart, D J Butler

Abstract

Field stimulation responses of rat urinary bladder detrusor smooth muscle were unaffected by atropine, phentolamine, propranolol, caffeine and theophylline. After caffeine or theophylline treatment, previously quiescent detrusor preparations developed pronounced spontaneous contractile activity. Both natural spontaneous contractile activity and field stimulation responses were eliminated in Ca-free EGTA media. After washout, both kinds of activity returned but over quite different time scales. At moderate levels of K+-induced depolarization which inactivate fast Ca-channels, field stimulation responses persisted and additively superimposed upon the K+-induced tension, suggesting that field stimulation-induced depolarization had activated slow voltage-dependent Ca-channels. Almost 61% of detrusor muscle preparations examined showed some spontaneous contractile activity. Such preparations were more sensitive to K+-induced depolarization than quiescent preparations and K+-depolarization greatly accelerated the spontaneous activity of these muscle strips. The slow Ca-channel blockers nifedipine and verapamil eliminated field stimulation responses in the 10(-6)-10(-5) M range, but octylonium bromide was far less effective even at 10...Continue Reading

References

May 1, 1978·British Journal of Pharmacology·G BurnstockL Kasakov
Jan 1, 1977·Annual Review of Pharmacology and Toxicology·A Fleckenstein
Jan 1, 1979·Annual Review of Physiology·A Fabiato, F Fabiato
Oct 1, 1979·Circulation Research·R A OlssonJ McLean
Feb 1, 1976·Japanese Journal of Pharmacology·J T Cheng
Jan 1, 1985·General Pharmacology·G Burnstock, C Kennedy
Jan 1, 1974·British Journal of Pharmacology·L B CobbinM H Maguire
Nov 1, 1974·The Journal of Physiology·R A Chapman, D J Miller
Jan 1, 1972·Pflügers Archiv : European journal of physiology·M KohlhardtA Fleckenstein
Jan 1, 1972·Pflügers Archiv : European journal of physiology·C J MayerT Casteels
Oct 1, 1970·The Journal of Physiology·N Ambache, M A Zar
Jan 1, 1981·Basic Research in Cardiology·W G Nayler, P Poole-Wilson
Dec 1, 1980·Circulation Research·R M Berne
Jan 1, 1983·The Journal of Physiology·A F BradingZ D Scripnyuk
Mar 1, 1982·Circulation Research·W P Dole, V S Bishop
Mar 1, 1980·Canadian Journal of Physiology and Pharmacology·J Church, T T Zsotér

❮ Previous
Next ❯

Citations

May 31, 1990·Neuroscience Letters·C G AcevedoJ P Huidobro-Toro
Jan 1, 1991·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·F I Alohan
Jul 1, 1993·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·S M Mahmod, H Huddart
Jun 18, 2002·European Journal of Pharmacology·Sefa ResimAtilla Dikmen
Feb 1, 1997·The Journal of Urology·M S DamaserR M Levin
Apr 1, 2000·BJU International·I W MillsJ G Noble
Nov 23, 2013·Purinergic Signalling·Geoffrey Burnstock
Nov 1, 1989·British Journal of Pharmacology·C A MaggiA Meli
Jan 1, 1988·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·H Huddart, R B Hill

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.