Field stimulation responses of rat urinary bladder detrusor smooth-muscle. Dependence upon slow calcium channel activity determined by K+ depolarization and calcium antagonists

General Pharmacology
H Huddart, D J Butler


Field stimulation responses of rat urinary bladder detrusor smooth muscle were unaffected by atropine, phentolamine, propranolol, caffeine and theophylline. After caffeine or theophylline treatment, previously quiescent detrusor preparations developed pronounced spontaneous contractile activity. Both natural spontaneous contractile activity and field stimulation responses were eliminated in Ca-free EGTA media. After washout, both kinds of activity returned but over quite different time scales. At moderate levels of K+-induced depolarization which inactivate fast Ca-channels, field stimulation responses persisted and additively superimposed upon the K+-induced tension, suggesting that field stimulation-induced depolarization had activated slow voltage-dependent Ca-channels. Almost 61% of detrusor muscle preparations examined showed some spontaneous contractile activity. Such preparations were more sensitive to K+-induced depolarization than quiescent preparations and K+-depolarization greatly accelerated the spontaneous activity of these muscle strips. The slow Ca-channel blockers nifedipine and verapamil eliminated field stimulation responses in the 10(-6)-10(-5) M range, but octylonium bromide was far less effective even at 10...Continue Reading


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