Field study of pneumonia in vaccinated cattle associated with incorrect vaccination and Pasteurella multocida infection

The Veterinary Record
W M Crawshaw, G L Caldow

Abstract

This field study used data on the vaccine courses against bovine respiratory disease sold by one pharmaceutical company in conjunction with pharmacovigilance data to explore reported suspected lack of expected efficacy and the reasons for this. The study ran from May 1, 2007, to April 30, 2010, and covered vaccines sold in Scotland and part of Northumberland. In total, 83 groups of cattle reported suspected lack of expected efficacy, representing 1.6 per cent of the 804,618 vaccine courses sold. It was possible to investigate 45 of these outbreaks in depth using a standard questionnaire and diagnostic protocol. Vaccine usage outwith the specific product characteristics (SPC) occurred in 47 per cent of cases (21/45). The proportion of vaccination courses used where a pathogen contained in the vaccine was detected in the diseased cattle and vaccine use was consistent with the SPC was estimated at 0.12 per cent of the courses sold. Pasteurella multocida was the most common pathogen detected and was found in 21 of the outbreaks. For outbreaks where a pathogen contained in the vaccine was detected, P. multocida was found at a significantly greater frequency (P=0.03) where vaccine use was compliant with the SPC (five of six outbreaks...Continue Reading

References

Jul 1, 2009·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Robert W FultonAmy Reck
Jul 14, 2010·The Veterinary Clinics of North America. Food Animal Practice·Dee GriffinD Scott McVey
Jul 14, 2010·The Veterinary Clinics of North America. Food Animal Practice·Vickie L Cooper, Bruce W Brodersen
Oct 25, 2011·Irish Veterinary Journal·Ingrid LorenzSimon J More

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Citations

Oct 25, 2016·Veterinary Microbiology·Conny TurniPat Blackall
Jan 26, 2017·Microbial Pathogenesis·Alexey V NefedchenkoAlexandra O Sementsova

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