Field Study on the Immunological Response and Protective Effect of a Licensed Autogenous Vaccine to Control Streptococcus suis Infections in Post-Weaned Piglets

Vaccines
Lorelei CorsautMariela Segura

Abstract

Streptococcus suis is one of the most important bacterial pathogens in weaned piglets and responsible for serious economic losses to the swine industry. Currently, mostly autogenous vaccines composed of killed bacteria (bacterins) are available. However, immunological and protective data from field studies are missing. We report for the first time a comparative field study on the immunological response induced by an autogenous vaccine applied to either piglets or sows in a farm with recurrent S. suis problems. (I) Piglets from non-vaccinated sows received an autogenous bacterin during the first week and at three weeks of age. (II) Sows received the vaccine at five and three weeks pre-farrowing and piglets were non-vaccinated. Levels, isotype profile and opsonophagocytosis capacity of the serum antibodies induced by vaccination were evaluated. Vaccination of piglets failed to induce an active immune response. Vaccination of sows induced a significant increase in anti-S. suis antibodies, mainly composed of IgG1. However, isotype switching was modulated by the S. suis serotype included in the vaccine formulation. Despite this antibody increase in vaccinated sows, transfer of maternal immunity to piglets was not different from the ...Continue Reading

References

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Oct 16, 2015·Expert Review of Vaccines·Mariela Segura
Apr 27, 2016·Infection and Immunity·Guillaume Goyette-DesjardinsMariela Segura

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