Field test results using the BioPEPR cervical smear prescreening system

Cytometry
D J ZahniserR T Van de Walle

Abstract

BioPEPR is a cathode ray tube scanning device that has been developed for the prescreening of cervical smears. Cervical samples are collected in suspension, syringed, counted and spread across a microscope slide. Feulgen-Thionine with Congo Red is used as the staining procedure. Fields of 6 X 8 mm are scanned at 1 mu resolution, using an intermediate photographic step. Morphologic parameters of the cells are measured, as called for by a hierarchical decision strategy. Analysis speed is currently about 4 min per smear; improvements of at least a factor of four are expected. A field test of BioPEPR is being undertaken in cooperation with a local population screening program. In the study two smears are made from each woman; the first is prepared according to the Papanicolaou technique while the second is prepared and stained according to the BioPEPR methods. In addition to smears from the population screening program a number of possibly abnormal smears are obtained from several gynecological clinics. To date approximately 3500 "second" smears have been analyzed by the BioPEPR system. The results show a missed positive rate on the order of a few percent (no missed positives were more severe than a slight dysplasia), and a false a...Continue Reading

References

Jan 1, 1979·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·D J ZahniserR T Van de Walle

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Citations

Jun 29, 2010·Cognitive Psychology·Aaron S Benjamin, Jonathan Tullis
Feb 14, 2019·Biomedical Engineering Online·Wasswa WilliamJohnes Obungoloch
Jul 19, 2019··Annabella Habinka BASAZA-EJIRIWasswa WILLIAM

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