Fifteen-year follow-up of pulmonary function in individuals heterozygous for the cystic fibrosis phenylalanine-508 deletion

The Journal of Allergy and Clinical Immunology
M DahlA Tybjaerg-Hansen

Abstract

In a cross-sectional study, we previously showed that cystic fibrosis phenylalanine-508 deletion (DeltaF508) heterozygosity may be overrepresented among individuals with asthma. Using 15-year follow-up data from the Copenhagen City Heart Study, we now further explore this relationship. As part of 3 surveys in 1976 to 1978, 1981 to 1983, and 1991 to 1994, we measured pulmonary function and asked all participants about asthma and pulmonary risk factors. There was no difference in annual decline in lung function between DeltaF508 heterozygotes and noncarriers overall; however, among individuals with familial asthma, the annual declines in FEV(1) and forced vital capacity (FVC) were 49 and 36 mL in DeltaF508 heterozygotes versus 24 and 17 mL in noncarriers (P =.01 and P =.12, respectively). Cross-sectionally based on triple measurements, FEV(1) and FVC in individuals aged 20 to 70 years were lower in heterozygous participants versus noncarriers (P =.02 and P =.004, respectively). The average reduction of FEV(1) and FVC in DeltaF508 heterozygotes versus noncarriers was 70 mL (P =.06) and 136 mL (P =.008). Finally, 10% of carriers reported asthma versus 7% of noncarriers (P =.02), resulting in an odds ratio of 2.0 (1.3-3.2) for asthm...Continue Reading

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Citations

Oct 11, 2005·Respiratory Research·Morten DahlBørge G Nordestgaard
Dec 17, 2004·Annals of Clinical Microbiology and Antimicrobials·Terence E McManusStuart J Elborn
May 14, 2009·International Journal of Chronic Obstructive Pulmonary Disease·Morten Dahl, Børge G Nordestgaard
Feb 13, 2014·Respiratory Research·S Vamsee RajuSteven M Rowe
May 8, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T E EatonG R Cutting
Jun 20, 2013·Pediatric Allergy, Immunology, and Pulmonology·Katarina MilosevicDragica Radojkovic
May 9, 2006·Respiratory Medicine·Monica Cheng Munthe-KaasKristin Eiklid
Nov 6, 2010·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Nicola ScichiloneVincenzo Bellia
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Aug 3, 2010·Allergologia et immunopathologia·J AntunesJ Cavaco
Jun 5, 2021·PloS One·Astrid Crespo-LessmannUNKNOWN Emerging Asthma Group

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