Fifteen years of irinotecan therapy for pediatric sarcoma: where to next?

Clinical Sarcoma Research
Lars Wagner

Abstract

Over the past 15 years, irinotecan has emerged as an important agent for treating pediatric sarcoma patients. This review summarizes the activity noted in previous studies, and outlines current issues regarding scheduling, route of administration, and amelioration of side effects. Also discussed are new pegylated and nanoliposomal formulations of irinotecan and its active metabolite, SN-38, as well as future plans for how irinotecan may be used in combination with other conventional cytotoxic as well as targeted agents.

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Methods Mentioned

BETA
xenografts
genotyping
xenograft

Clinical Trials Mentioned

NCT01055314
NCT02095132
NCT02013336

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