PMID: 11332669May 3, 2001Paper

Fifth vaccination with dipthteria, tetanus and acellular pertussis is beneficial in four- to six-year-olds

The Pediatric Infectious Disease Journal
M E PichicheroJ A England

Abstract

Diphtheria, tetanus and pertussis serum antibody titers were assessed before a fifth dose of diphtheria-tetanus-acellular pertussis (DTaP) or diphtheria-tetanus-whole cell pertussis (DTwP) vaccination at age 4 to 6 years. Healthy children who had participated in a series of National Institutes of Health-sponsored trials assessing DTwP and DTaP vaccines provided prevaccination sera before a fifth dose of DTwP or DTaP. The trial design was prospective, randomized and double blind. Diphtheria, tetanus and pertussis antibody titers were measured by enzyme-linked immunosorbent assay. Pertussis results are expressed in enzyme-linked immunosorbent assay units/ml based on US Food and Drug Administration reference sera. Tetanus and diphtheria toxin concentrations are expressed in IU/ml with a WHO international reference sera as a standard. For diphtheria 100% of the children had antibody titers above the minimum protective level of 0.01 IU/ml and 86 to 100% (depending on prior vaccine product) had titers >0.1 IU/ml. However, only 0 to 40% of the children had antibody titers > or =1.0 IU/ml, a titer associated with more certain durable protection. For tetanus none of the children had an antibody titer below 0.01 IU/ml, and 93 to 100% had...Continue Reading

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Citations

Jun 28, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·William A McCannDennis R Ownby
Nov 14, 2003·The Pediatric Infectious Disease Journal·Siranda Torvaldsen, Peter B McIntyre
Apr 14, 2005·Public Health·T InandiN Hacialioglu
Oct 26, 2021·The Cochrane Database of Systematic Reviews·Gladymar Perez ChaconTom Snelling
Oct 17, 2007·Pediatrics·Mark J AbzugUNKNOWN International Maternal Pediatric Adolescent AIDS Clinical Trials Group P1024 Protocol Team

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