Fifty years of experience with propylthiouracil-associated hepatotoxicity: what have we learned?

The Journal of Clinical Endocrinology and Metabolism
K V WilliamsL A Burmeister

Abstract

The aim of this study was to determine the optimal management of patients with propylthiouracil (PTU) hepatotoxicity. A MEDLINE search for English language cases of PTU hepatotoxicity between 1966 and April 1996 was performed, and additional cases were cross-referenced. Twenty-seven cases were selected based on the availability of information on patient management after the onset of hepatotoxicity. Eighty-five percent of the selected cases met this criterion. A detailed summary of the management of two cases of PTU hepatotoxicity at our institutions is also provided. Although most patients recovered once PTU was stopped, seven patients died. Patients with PTU hepatotoxicity who survived were more likely to have received 131I during the course of their illness than those who died (P < 0.03, by Fisher's exact test). In our two patients, hyperbilirubinemia was linearly associated with progressively decreasing T4 levels (r = 0.91; P < 0.001) despite the presence of clinical thyrotoxicosis in one of the patients. These findings demonstrate the need for appropriate clinical evaluation and treatment of thyroid disease during the course of hepatotoxicity. Additionally, we report the first pediatric patient with PTU hepatotoxicity to un...Continue Reading

References

Jul 1, 1979·The Journal of Clinical Endocrinology and Metabolism·I J ChopraD H Solomon
Aug 1, 1979·British Journal of Anaesthesia·L Hasselstrøm, M B Kristoffersen
Feb 1, 1979·Annals of Internal Medicine·D S CooperG H Daniels
Jan 1, 1975·The Journal of Clinical Endocrinology and Metabolism·C H EmersonR D Utiger
Feb 1, 1975·Archives of Internal Medicine·M S Fedotin, L G Lefer
Feb 1, 1975·Annals of Internal Medicine·L N Parker
Nov 1, 1975·Gut·M LunzerS Sherlock
May 1, 1991·Experimental and Clinical Endocrinology·J H RomaldiniR S Werner
Sep 1, 1991·Gut·R D HughesA E Gimson
Dec 1, 1990·Journal of Endocrinological Investigation·C Y HayashidaE H Yamashiro-Kanashiro
Jan 1, 1990·The Korean Journal of Internal Medicine·H KangJ Y Yoo
Aug 1, 1989·Gastroenterology·J G O'GradyR Williams
Feb 1, 1989·Journal of Clinical Gastroenterology·G OzenneE Bercoff
Mar 1, 1987·Annals of Internal Medicine·B J ZitelliD H Van Thiel
Dec 3, 1987·The New England Journal of Medicine·H OrregoY Israel
Jan 1, 1986·Journal of Toxicology. Clinical Toxicology·D S SeidmanI Blum
Jul 1, 1986·Archives of Internal Medicine·C AyensaJ M Cia
Oct 1, 1985·Drug Intelligence & Clinical Pharmacy·B Z GartyZ Laron
Nov 1, 1985·Archives of Internal Medicine·C A BlochL M Dolan
Nov 18, 1968·JAMA : the Journal of the American Medical Association·C E BeckerJ Robbins
Feb 26, 1973·JAMA : the Journal of the American Medical Association·M G FischerA Miller
Nov 22, 1984·The New England Journal of Medicine·D S Cooper
Apr 1, 1983·The American Journal of Medicine·D S RossE C Ridgway
Aug 18, 1983·The New England Journal of Medicine·W W DinsmoreM E Callender
Apr 1, 1982·Archives of Internal Medicine·M M SafaniP Rudd
Feb 1, 1981·American Journal of Diseases of Children·B A BuckinghamM D Kogut
Apr 1, 1995·The Journal of Clinical Endocrinology and Metabolism·D M ArabR S Rittmaster
Sep 1, 1994·Southern Medical Journal·S A Westphal
Oct 1, 1993·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·M P LewisM P Singh
Dec 1, 1995·Thyroid : Official Journal of the American Thyroid Association·L A Burmeister
Jul 1, 1952·The American Journal of Physiology·S B BARKER, H M KLITGAARD
May 2, 1953·Journal of the American Medical Association·H ROSENBAUM
Nov 12, 1953·The New England Journal of Medicine·M J EISEN
Feb 23, 1952·Journal of the American Medical Association·A R COLWELLS J LANG
Aug 1, 1950·The Journal of Clinical Investigation·J D MYERSB C HOLLAND
Oct 18, 1947·Journal of the American Medical Association·H J LIVINGSTON, S F LIVINGSTON
Feb 9, 1946·Journal of the American Medical Association·F D MOORE

❮ Previous
Next ❯

Citations

Jul 23, 2004·Archives of Disease in Childhood·G Birrell, T Cheetham
Jun 5, 1998·Archives of Disease in Childhood·T D CheethamE P Wraight
Oct 13, 2007·BMJ : British Medical Journal·P J D OwenA J Godkin
Dec 1, 2009·International Journal of Pediatric Endocrinology·Scott A Rivkees, Donald R Mattison
Jan 15, 2011·International Journal of Endocrinology·Andres F CarrionRavi K Ghanta
Mar 26, 2010·The Journal of Clinical Endocrinology and Metabolism·Ana B EmilianoDavid S Cooper
May 27, 2005·PLoS Medicine·Ali S AlzahraniAli Sultan
Jan 27, 2006·PLoS Medicine·Chukwuma Ogbonna Ekpebegh, Naomi Sharlene Levitt
Aug 21, 2003·Lancet·David S Cooper
Apr 16, 1998·Endocrinology and Metabolism Clinics of North America·D S Cooper
Jun 4, 2014·Endocrinology and Metabolism Clinics of North America·Becky T MuldoonHenry B Burch
Feb 16, 2013·The American Journal of Medicine·Aroop PalLeland Graves
Aug 3, 2010·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Manuel Penín AlvarezRicardo García-Mayor García
Aug 12, 2015·European Journal of Internal Medicine·Angelos KyriacouAkheel A Syed
Aug 6, 2010·Obstetrics and Gynecology Clinics of North America·Diana L Fitzpatrick, Michelle A Russell
Oct 21, 2005·International Journal of Clinical Practice·S AydemirY Ustundag
May 18, 2004·The Surgical Clinics of North America·Elizabeth N Pearce, Lewis E Braverman
Aug 19, 2015·Endocrinology, Diabetes & Metabolism Case Reports·Nicola TuftonMona Waterhouse
Oct 5, 2013·Best Practice & Research. Clinical Gastroenterology·Patrizia Burra
Feb 13, 2014·The Journal of Pediatrics·Roberto GastaldiAndrea Corrias
Jun 25, 2016·BMC Research Notes·R D S S WickramasingheR Premaratna
Nov 18, 2015·International Journal of Endocrinology·Rendong ZhengChao Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Pediatric Gastroenterology and Nutrition
M M Jonas, M S Eidson
Pediatric Pathology & Laboratory Medicine : Journal of the Society for Pediatric Pathology, Affiliated with the International Paediatric Pathology Association
R Deidiker, D E deMello
Current Opinion in Endocrinology, Diabetes, and Obesity
Daniel Glinoer, David S Cooper
© 2021 Meta ULC. All rights reserved