Abstract
Catecholamines are recognized to play an important part in the fight-or-flight response to impending stress. Catecholamine and other phase-reactant levels are raised in the first 24 h following acute stress, but the bigger picture of their action on the organism is unavailable. In this article, we examine their actions in light of the theory of phase transitions borrowed from the numerate sciences. Phase transitions involve changes in the state of matter or an organism with a common example of what is termed a first-order phase transition (sudden change) being provided by the popular expression "the straw that broke the camel's back." We propose that the response to catecholamines follows a triphasic response: a Phase I response is the fight-or-flight response to impending stress that protects the animal. With mild to intermediate stress, the Phase II or forbearance response allows it to tolerate the physiological upset. With severe stress, however, severe vital organ vasoconstriction leads to a quick death. The present theory has value in understanding the clinical picture in acute stress. Phase II or Forbearance Phase corresponds to Classes I, II, and III of hemorrhagic shock, and Phase III or Fortitude Phase to Class IV. Thu...Continue Reading
Citations
Mar 3, 2011·Applied Psychophysiology and Biofeedback·Quinn A MorarendDavid C Holmes
Sep 16, 2006·Biological Chemistry·Fumio Matsumura, Christoph F A Vogel
Nov 28, 2009·Sangyō eiseigaku zasshi = Journal of occupational health·Mutsuhiro Nakao
Jun 21, 2015·Molecular and Cellular Neurosciences·Sonia PodvinVivian Hook
Nov 4, 2015·Scientific Reports·Natalie BordagJoachim Selbig
Sep 30, 2014·Psychosomatic Medicine·Paul A DennisJean C Beckham
Aug 28, 2007·Experimental Biology and Medicine·Sharon DemorrowGianfranco Alpini
Apr 8, 2020·Nutrients·Jasminka Z IlichDario Boschiero
Jan 24, 2018·Molecular and Cellular Endocrinology·Amy C KellySean W Limesand
Apr 17, 2021·General and Comparative Endocrinology·Emma M JepsenAndré Ganswindt