Fighting against evolution of antibiotic resistance by utilizing evolvable antimicrobial drugs

Current Genetics
Mehmet Fatih Cansizoglu, Erdal Toprak

Abstract

Antibiotic resistance is a worldwide public health problem (Bush et al. in Nat Rev Microbiol 9:894-896, 2011). The lack of effective therapies against resistant bacteria globally leads to prolonged treatments, increased mortality, and inflating health care costs (Oz et al. in Mol Biol Evol 31:2387-2401, 2014; Martinez in Science 321:365-367, 2008; Lipsitch et al. in Proc Natl Acad Sci USA 97:1938-1943, 2000; Taubes in Science 321:356-361, 2008; Laxminarayan et al. in Lancet, 2016; Laxminarayan et al. in Lancet Infect Dis 13:1057-1098, 2013). Current efforts towards a solution of this problem can be boiled down to two main strategies: (1) developing of new antimicrobial agents and (2) searching for smart strategies that can restore or preserve the efficacy of existing antimicrobial agents. In this short review article, we discuss the need for evolvable antimicrobial agents, focusing on a new antimicrobial technology that utilizes peptide-conjugated phosphorodiamidate morpholino oligomers to inhibit the growth of pathogenic bacteria by targeting bacterial genes.

References

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Citations

May 3, 2020·Pest Management Science·Andrés F Sandoval-MojicaKirsten S Pelz-Stelinski
Aug 6, 2019·Frontiers in Pharmacology·Darya NovopashinaAlya Venyaminova
May 8, 2018·Frontiers in Microbiology·Yuchen Nan, Yan-Jin Zhang
Sep 30, 2021·Organic & Biomolecular Chemistry·Nóra DebreczeniAnikó Borbás

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