Fighting Antibiotic-Resistant Klebsiella pneumoniae with "Sweet" Immune Targets

MBio
Roberto Adamo, Immaculada Margarit

Abstract

Antibiotics and vaccines have greatly impacted human health in the last century by dramatically reducing the morbidity and mortality associated with infectious diseases. The recent challenge posed by the emergence of multidrug-resistant bacteria could possibly be addressed by novel immune prophylactic and therapeutic approaches. Among the newly threatening pathogens, Klebsiella pneumoniae is particularly worrisome in the nosocomial setting, and its surface polysaccharides are regarded as promising antigen candidates. The majority of Klebsiella carbapenem-resistant strains belong to the sequence type 158 (ST258) lineage, with two main clades expressing capsular polysaccharides CPS1 and CPS2. In a recent article, S. D. Kobayashi and colleagues (mBio 9:e00297-18, 2018, https://doi.org/10.1128/mBio.00297-18) show that CPS2-specific IgGs render ST258 clade 2 bacteria more sensitive to human serum and phagocytic killing. E. Diago-Navarro et al. (mBio 9:e00091-18, 2018, https://doi.org/10.1128/mBio.00091-18) generated two murine monoclonal antibodies recognizing distinct glycotopes of CPS2 that presented functional activity against multiple ST258 strains. These complementary studies represent a step toward the control of this dangerou...Continue Reading

References

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Jan 10, 2018·Nature Medicine·Kathrin U JansenAnnaliesa S Anderson
Mar 17, 2018·FEMS Microbiology Reviews·Francesca MicoliRoberto Adamo

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Citations

Nov 30, 2019·Frontiers in Cellular and Infection Microbiology·L Ponoop Prasad Patro, Thenmalarchelvi Rathinavelan
Sep 12, 2020·International Journal of Molecular Sciences·Daria ArtyszukJolanta Lukasiewicz

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

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