Filaggrin sequencing and bioinformatics tools.

Archives of Dermatological Research
David J MargolisKatherine L Nathanson

Abstract

Atopic dermatitis (AD) is a common illness that most commonly originates in childhood, but can be seen in all ages. Filaggrin (FLG) loss of function variants have been associated with the onset and severity of atopic dermatitis and are the most common genetic association with AD. Previous studies have shown variability in the frequency of FLG variants. We have recently demonstrated that previous FLG genotyping methods were inadequate for proper genotyping. In this concise report, we show that genotyping using a popular older informatics program is problematic. In fact, publications that used the older program likely do not properly capture all FLG variants.

References

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Citations

Jan 26, 2021·The Journal of Investigative Dermatology·Yaqian ZhuDavid Margolis
Feb 16, 2021·Current Treatment Options in Allergy·Jayanta Gupta, David J Margolis
Apr 18, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·David J MargolisDimitri S Monos

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Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.